VIDEO: Expert discusses HCV treatment during pregnancy, mother-to-child transmission
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BOSTON — In this video, Nancy S. Reau, MD, FAASLD, AGAF, reviews three abstracts presented at The Liver Meeting related to pregnancy and pediatric treatments for hepatitis C virus infection.
The first abstract described ovarian failure due to extrahepatic manifestations of HCV. Researchers reported that HCV increased the risk for premature ovarian failure from one in 18 in a non-HCV-infected group to one in seven.
“It’s a reminder that if you have a group of individuals that are being evaluated for infertility, checking for hepatitis C virus is probably going to be important,” Reau, professor and associate director of organ transplantation at Rush University, said. “But also, that we are not neglecting effective cure in these women of childbearing age, because they do seem to have a higher rate of premature ovarian failure.”
The second abstract assessed transmission of HCV among perinatal and pediatric populations. Researchers gathered information from referral centers for children with HCV, and in about a year, identified nearly 100 children aged 13 to 18 years with HCV infection through vertical transmission.
“They found that using DAA treatment led to a 100% cure rate,” Reau said. “And all of these individuals were felt to have been identified through vertical transmission.”
The final abstract reported interim results from the STORC study, which showed that treatment was safe and effective for pregnant women.
“We still think that treatment before pregnancy is ideal,” Reau said. “But if you have a woman where treatment during pregnancy is really the best fit for that woman, this is exciting data that shows that this can be safe and effective.”
References:
- Chappell C, et al. Safety, tolerability and outcomes of sofosbuvir/velpatasvir in treatment of chronic hepatitis C virus during pregnancy: Interim results from the STORC study. Presented at: The Liver Meeting; Nov. 10-14, 2023; Boston (hybrid meeting).
- Kelly DA, et al. Eliminating HepC in children; care closer to home. Presented at: The Liver Meeting; Nov. 10-14, 2023; Boston (hybrid meeting).
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Telep LE, et al. Early menopause and primary ovarian insufficiency in women with and without chronic hepatitis c: a retrospective observational study of women in the United States. Presented at: The Liver Meeting; Nov. 10-14, 2023; Boston (hybrid meeting).
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