VIDEO: Race, biomarkers among risk factors for HCC in spontaneously cleared HCV
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BOSTON — According to an abstract at The Liver Meeting, patients of Hispanic ethnicity who had elevated liver enzymes at baseline remained at increased risk for hepatocellular carcinoma, despite spontaneously clearing hepatitis C virus.
The retrospective study included more than 20,000 individuals from the U.S. Veterans Affairs Administration who tested hepatitis C antibody positive and PCR negative without treatment. Of these patients, 421 developed HCC.
“A lot of that was going to be driven by alcohol use disorder or fatty liver disease, but even when they eliminated those concomitant factors, they found that nearly 100 individuals seemed to have developed HCC without these risk factors,” Nancy S. Reau, MD, FAASLD, AGAF, professor and section chief of hepatology and associate director of organ transplantation at Rush University, told Healio.
Researchers determined that higher risk for HCC was associated with Hispanic ethnicity, elevated alanine aminotransferase at baseline, and max Fibrosis-4 of at least 1.45 within a year of diagnosis.
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Hitawala AA, et al. Hepatocellular carcinoma risk in spontaneously cleared hepatitis C patients. Presented at: The Liver Meeting; Nov. 10-14, 2023; Boston (hybrid meeting).
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