VIDEO: ‘Unique’ protocol expands transplant pool to include HCV-infected donors

ByNorah Terrault, MD, MPH, FAASLD

ByMarley V. Ghizzone

Fact checked byHeather Biele

BOSTON — In this video, Norah Terrault, MD, MPH, FAASLD, spoke with Healio about a presentation from The Liver Meeting on “The Toronto Protocol,” an ultra-short course of glecaprevir/pibrentasvir with ezetimibe.

According to Terrault, the 7-day protocol is designed to prevent chronic hepatitis C virus infection when transplanting solid organs from HCV-infected donors to noninfected recipients.

“That combination is successful in preventing infection in these solid organ transplants of kidney, heart and liver,” Terrault, professor of medicine, chief of gastroenterology and liver diseases, and Neil Kaplowitz Endowed Chair in Liver Diseases Research at the University of Southern California Keck School of Medicine, told Healio. “That is also a very unique, important and cost-effective approach to expanding the donor pool and potentially having more patients receive organs rather than having these organs not be used.”

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Healio Interviews

Disclosures: Terrault reports receiving institutional grant support from NIH; institutional grant support for clinical trials from Durect Corp., Eiger Pharmaceuticals, Genentech-Roche, Gilead Sciences, GSK, Helio Health and Madrigal; honoraria for speaking at conferences or other lectures from AASLD, The Asian Pacific Association for the Study of the Liver, Canadian Association for the Study of the Liver (CASL), Duke University, EASL, International Liver Transplantation Society (ILTS), GUILD Conference, Houston Methodist, Iowa University, University of Alabama at Birmingham and University of California; travel accommodations for lectures from AASLD, CASL, EASL, GUILD, ILTS, Iranian Association for the Study of Liver Diseases and Pakistan Society For The Study Of Liver Diseases; serving as president on the governing board of AASLD; serving as a steering committee member for Hepatitis B Foundation and HBV Forum; and being provided with educational materials from Clinical Care Options and Simply Speaking.

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VIDEO: ‘Unique’ protocol expands transplant pool to include HCV-infected donors

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