Liver/Biliary Disorders News

The addition of simvastatin plus rifaximin to standard therapy did not improve outcomes among patients with decompensated cirrhosis who were at high risk for clinical complications, according to a study published in JAMA.

Most pediatric transplant recipients who received live-attenuated viral vaccines after transplant developed protective antibodies that persisted for up to a year after vaccination with no significant safety events, researchers found.

Normothermic machine perfusion was linked to significant improvements in liver transplant clinical outcomes and reduced hospital resource use, especially among patients who received donation after circulatory death allografts, data show.

The AHFIRM trial did not demonstrate a beneficial effect of larsucosterol on 90-day mortality or the need for liver transplant among patients with severe alcohol-associated hepatitis, or AH, according to a study published in NEJM Evidence.

Approximately 14% of the U.S. population lives in rural areas, where access to health care may be limited by insurance coverage, geography and infrastructure, and provider shortages, according to HHS.

Despite decreased population-level hepatitis C virus screening in 2020, guidance to test all adults and during every pregnancy was associated with increased HCV screening for pregnant women, according to a research letter published in JAMA.

Metabolic surgery significantly lowered risk for major adverse liver outcomes vs. nonsurgical management among patients with obesity and compensated cirrhosis from metabolic dysfunction-associated steatohepatitis, according to study data.

Fecal microbiota transplant, regardless of dose or route, was safe and associated with reduced hepatic encephalopathy recurrence among patients with cirrhosis receiving lactulose and rifaximin, according to a study in Journal of Hepatology.

Injectable naltrexone had a more favorable gastrointestinal and liver safety profile compared with other medications for alcohol use disorder, according to a research letter published in Clinical Gastroenterology and Hepatology.