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Intestinal Disorders News

Antibiotics fall short of appendectomy for uncomplicated appendicitis in children
Among children with suspected nonperforated appendicitis, antibiotic management appeared inferior to appendectomy, according to results of a large, noninferiority trial published in The Lancet.
Anti-inflammatory therapies linked to reduced risk, incidence of Parkinson’s disease

In a large cohort of patients with autoimmune diseases, treatment with biologic disease-modifying antirheumatic drugs was associated with reduced incidence of Parkinson’s disease, data show.
Gut microbiota in older cancer survivors linked to cognitive function

ORLANDO, Fla. — An analysis of the gut microbiome among individuals who survived cancer revealed a significant association between the gut-brain axis, particularly in gut microbiota, metabolism and cognitive function, according to a poster.
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VIDEO: Greater reduction in parenteral support with apraglutide vs. placebo in SBS-IF
WASHINGTON — In a Healio video, Kishore R. Iyer, MBBS, shares results from the STARS study, in which weekly apraglutide significantly reduced parenteral support volume in patients with short bowel syndrome and intestinal failure.
What is proctalgia fugax and how is it managed?

Proctalgia fugax (fugax-fleeting) is characterized by brief episodes of rectal pain. Although a common problem, information regarding this disorder is limited because the published medical literature consists mostly of anecdotal reports and small case series.
Migraine, GI symptoms increase risk of adverse psychiatric comorbidities

DENVER — For those diagnosed with migraine, gastrointestinal issues or both, psychiatric comorbidities increase the risk of worsened physical and mental states, according to an expert at the American Academy of Neurology annual meeting.
STARS: Apraglutide reduces need for parenteral support in short bowel syndrome by week 24

Topline results from the phase 3 STARS trial showed apraglutide reduced dependency on parenteral support for adult patients with short bowel syndrome with intestinal failure at week 24, Ironwood Pharmaceuticals announced.
Prophylactic probiotic ‘ineffective’ in mitigating GI permeability associated with aspirin

Consumption of a prophylactic probiotic supplement of Lactobacilli did not prevent or mitigate the effects of gastrointestinal permeability associated with an acute aspirin challenge in healthy individuals, data showed.
‘Clinical features alone’ sufficient to assess need for small bowel obstruction surgery

Although CT imaging remains standard of care for determining surgical management needs for small bowel obstruction, clinical features alone performed equally well and with greater accuracy, according to data published in JAMA Network Open.
Q&A: Keep ‘jet belly’ at bay by limiting highly fermentable foods before, during flights

Nearly 7.5 million Americans are expected to reach their holiday destinations by plane this year — a daunting task for most individuals but even more challenging for those with gastrointestinal disorders.
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