VIDEO: 7 general principles ‘help to frame’ routine preventive vaccination in IBD
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In a Healio video exclusive, Gil Y. Melmed, MD, MS, outlines seven principles supported by literature that “help to frame” how providers should address routine preventive vaccination for patients with inflammatory bowel disease.
“It was a great pleasure to present at the GUILD meeting with respect to vaccinating your patients with inflammatory bowel disease,” Melmed, director of clinical trials at the Inflammatory Bowel Disease Center at Cedars-Sinai in Los Angeles, said. “We talked about some general principles of vaccination for patients with IBD that really help to frame how we think about routine preventive vaccinations in our patients with IBD, particularly those that may be at increased risk for specific infections on the basis of the medications that they are taking.”
According to Melmed, the seven principles are:
- Vaccine efficacy “may be blunted” by certain medications.
- Despite the potential for decreased vaccine response, therapy and the timing of vaccine schedules should not be adjusted.
- Post-vaccination titers may wane faster in patients who are on certain medications; this should not “directly and practically” affect whether or not certain vaccines are delivered.
- Vaccines do not cause IBD flares, which has been proven “very robustly” by data from COVID vaccination registries as well as for other non-COVID vaccines.
- Among patients on cyclic medications, it does not matter where in the treatment cycle they decide to be vaccinated.
- Live vaccines should be avoided among patients on immunosuppressive therapies.
- Time vaccination to when the patients are most likely to receive it, for example, when they are in the office. Utilize those opportunities to administer more than one vaccine at a time.
Melmed further touched upon specific recommendations for vaccines that prevent serious respiratory infection such as influenza, COVID-19, pneumonia and respiratory syncytial virus, as well as vaccines for herpes zoster, HPV and hepatitis A and B viruses.
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Melmed G. How to guide: Vaccinating your patients with IBD. Presented at: GUILD Conference; Feb. 18-21, 2024 (hybrid meeting).
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