VIDEO: Inflammation likely ‘driving the risk’ for cardiovascular events in IBD
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In a Healio video exclusive, Edward V. Loftus Jr., MD, discusses data he presented at the GUILD Conference, which show patients with inflammatory bowel disease are at increased risk for cardiovascular events, likely driven by inflammation.
“Interestingly, there are multiple studies showing that IBD patients do have a slightly higher risk for cardiovascular events,” Loftus, the Maxine and Jack Zarrow Family Professor of Gastroenterology at the Mayo Clinic, told Healio. “Fortunately, the risk isn’t too high, but it is elevated relative to non-IBD controls — anywhere from 20% to even 100% elevated. It varies among studies.”
Among the studies discussed in this video is one in which patients with IBD were “on average” two to three times more likely to experience a cardiovascular event compared with matched controls, despite lower rates of family history of coronary disease, hypertension, diabetes and hyperlipidemia.
“Even though the IBD patients have lower amounts of the traditional risk factors, they did have an elevated risk,” Loftus said.
Additional studies demonstrate that certain medications, including anti-tumor necrosis factor agents, may have a “slightly protective” effect against the development of cardiovascular events.
“A lot of the circumstantial evidence suggests that it’s the amount of inflammation in the body that’s driving the risk,” Loftus said.
Check out the video for more details on studies of Janus kinase inhibitors and other biologics, as well as the influence of demographic and lifestyle factors on patient risk.
References:
- Alayo QA, et al. Clin Gastroenterol Hepatol. 2023;doi:10.1016/j.cgh.2022.08.035.
- Aniwan A, et al. Clin Gastroenterol Hepatol. 2018;doi:10.1016/j.cgh.2018.04.031.
- Dheyriat A, et al. Clin Gastroenterol Hepatol. 2022;doi:10/1016/j.cgh.2022.06.011.
- Kristensen LE, et al. Ann Rheum Dis. 2023;doi:10.1136/ard-2022-223715.
- Ytterberg SR, et al. N Engl J Med. 2022;doi:10.1056/NEJMoa2109927.
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Loftus E. Cardiovascular risk in IBD: Another reason to control disease activity? Presented at: GUILD Conference; Feb. 18-21, 2024 (hybrid meeting).
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