Diagnosis and Advanced Diagnostic Techniques

Reviewed on June 20, 2024

Introduction

Diagnosing food allergies is a crucial first step toward the efficient management of these potentially life-threatening conditions. By accurately identifying the specific allergens that trigger adverse reactions, healthcare providers can tailor effective treatment plans and help patients navigate dietary restrictions with confidence. All of the 9 major food allergens (see Overview) can lead to the development of IgE-mediated allergies. The most common food allergens associated with non-IgE-mediated allergies include milk, soybeans, grains (oats and rice) and eggs.

The first step in the diagnosis of food allergy is obtaining a comprehensive clinical history and carrying out a thorough physical examination. This assessment involves gathering information about the patient's symptoms, including their time of onset, duration, triggers and the treatments administered (if any) and their effectiveness, as well as any relevant medical history, such as previous allergic reactions or…

Introduction

Diagnosing food allergies is a crucial first step toward the efficient management of these potentially life-threatening conditions. By accurately identifying the specific allergens that trigger adverse reactions, healthcare providers can tailor effective treatment plans and help patients navigate dietary restrictions with confidence. All of the 9 major food allergens (see Overview) can lead to the development of IgE-mediated allergies. The most common food allergens associated with non-IgE-mediated allergies include milk, soybeans, grains (oats and rice) and eggs.

The first step in the diagnosis of food allergy is obtaining a comprehensive clinical history and carrying out a thorough physical examination. This assessment involves gathering information about the patient's symptoms, including their time of onset, duration, triggers and the treatments administered (if any) and their effectiveness, as well as any relevant medical history, such as previous allergic reactions or family history of allergies. Additionally, clinicians should consider the patient's history of other atopic conditions, including atopic dermatitis, asthma and allergic rhinitis, since there is conclusive evidence that these conditions are linked with food allergies. This information can help find the trigger of the reaction and guide the selection of further diagnostic tests. Moreover, to accurately assess the disease, diagnostic tools for food allergies should be used within the framework of clinical symptoms.

References

  • Anvari S, Miller J, Yeh CY, Davis CM. IgE-Mediated Food Allergy. Clinic Rev Allerg Immunol. 2019;57(2):244-260.
  • Fu L, Cherayil BJ, Shi H, et al. Overview of the Immunology of Food Allergy Food. Fu L, Cherayil BJ, Shi H, et al, eds. In: Food Allergy From Molecular Mechanisms to Control Strategies. Springer Nature Singapore; 2019:1-12.
  • Jeebhay MF, Bang B. Occupational Allergy and Asthma Associated with Inhalant Food Allergies. Lopata AL, ed. In: Food Allergy Molecular and Clinical Practice. Taylor & Francis Group, LLC; 2017:176-202.
  • Maciag MC, Bartnikas LM, Sicherer SH, et al. A Slice of Food Protein–Induced Enterocolitis Syndrome (FPIES): Insights from 441 Children with FPIES as Provided by Caregivers in the International FPIES Association. J Allergy Clin Immunol: In Practice. 2020;8(5):1702-1709.
  • Martin PE, Eckert JK, Koplin JJ, et al. Which infants with eczema are at risk of food allergy? Results from a population‐based cohort. Clin Experimental Allergy. 2015;45(1):255-264.
  • Meredith S, Nordman H. Occupational asthma: measures of frequency from four countries. Thorax. 1996;51(4):435-440.
  • Saf S, Borres MP, Södergren E. Sesame allergy in children: New insights into diagnosis and management. Pediatr Allergy Immunol. 2023;34(8):e14001.
  • Upton J, Nowak-Wegrzyn A. The Impact of Baked Egg and Baked Milk Diets on IgE- and Non-IgE-Mediated Allergy. Clinic Rev Allerg Immunol. 2018;55(2):118-138.
  • Zhang S, Sicherer S, Berin MC, Agyemang A. Pathophysiology of Non-IgE-Mediated Food Allergy. ImmunoTargets Ther. 2021;10:431-446.