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Therapeutics/Diagnostics News
‘No strong evidence’ to support discontinuation of GLP-1RAs prior to upper endoscopy
Although glucagon-like peptide-1 receptor agonist use prior to upper endoscopy was linked to a higher rate of retained gastric contents, evidence supports prolonged fasting as the “optimal approach” rather than routine discontinuation.
Skyrizi outperforms Stelara in endoscopic remission at week 48 in Crohn’s disease
Although Skyrizi was noninferior to Stelara in clinical remission at week 24, it was superior in endoscopic remission at week 48 in patients with moderate to severe Crohn’s disease, according to data from the SEQUENCE trial.
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Cardiovascular risk assessment recommended before use of small-molecule drugs in IBD
Although evidence suggests the risk for cardiovascular events with small-molecule drugs is low in patients with inflammatory bowel disease, experts advise screening for risk factors and stratification before initiation of therapy.
Vedolizumab improves clinical outcomes, induces mucosal healing in UC, chronic pouchitis
Vedolizumab not only induced endoscopic improvements in patients with chronic pouchitis, but also appeared to improve clinical outcomes at week 34, especially in those who achieved mucosal healing at week 14, research showed.
Vonoprazan-bismuth triple therapy eradicates H. pylori in up to 90.9% vs. standard care
A triple therapy of vonoprazan, amoxicillin and bismuth potassium citrate achieved an eradication rate of just over 90%, similar to that of the standard quadruple therapy, in patients with Helicobacter pylori infection, according to data.
Skyrizi bests placebo in clinical remission as induction, maintenance therapy for UC
Skyrizi significantly improved clinical remission rates as both induction and maintenance therapy vs. placebo in patients with moderately to severely active ulcerative colitis, according to data from the phase 3 INSPIRE and COMMAND trials.
Autonomous AI bests AI-assisted endoscopists in optical diagnosis of colorectal polyps
Autonomous AI exhibited “noninferior accuracy” for optical diagnosis of diminutive colorectal polyps vs. AI-assisted endoscopists, yet surpassed endoscopist accuracy in later pathology-based surveillance intervals, according to researchers.
Up-to-date HCC screening after HCV cure improves survival in patients with cirrhosis
Remaining current on screening for hepatocellular carcinoma correlated with a “survival benefit” in older adults with hepatitis C virus-related cirrhosis who achieved viral cure but later developed HCC, according to researchers.
Intestinal ultrasound may predict Stelara response at 1 year in Crohn’s disease
Multimodal intestinal ultrasound performed at 24 weeks can provide “useful information” for predicting endoscopic response at 1 year in patients with active Crohn’s disease initiating treatment with Stelara, according to researchers.
Fazirsiran lowers serum, liver concentrations of Z-AAT in alpha-1 antitrypsin deficiency
In a dose-dependent manner, fazirsiran reduced serum and liver concentrations of Z-AAT and also improved histological measures in patients with homozygous ZZ alpha-1 antitrypsin deficiency-associated liver disease, according to data.
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Headline News
Burnout, withdrawal remain ‘alarmingly high’ among physicians and residents
September 17, 20242 min read -
Headline News
Over one-third of adults not planning on receiving recommended vaccines this fall
September 18, 20242 min read -
Headline News
Popular home BP devices unable to provide accurate readings for millions due to sizing
September 19, 20242 min read