Therapeutics/Diagnostics News

PHILADELPHIA — Patients with type 2 diabetes on glucagon-like peptide-1 receptor agonists had significantly lower risk for pancreatic cancer compared with those on other antidiabetic therapies, regardless of weight, according to data.

The FDA approved the Stelara biosimilar, Selarsdi, as a 130 mg/26 mL single-dose IV infusion for adult patients with Crohn’s disease and ulcerative colitis, Alvotech and Teva Pharmaceuticals announced in a press release.

Changes in MRI-derived markers of iron-corrected T1 mapping and liver fat content appear effective at predicting histological response among patients treated for metabolic dysfunction-associated steatohepatitis, according to researchers.

Treatment with Rinvoq resulted in higher rates of closure of external openings and drainage resolution vs. placebo in perianal fistulizing Crohn’s disease, according to pooled data from the U-EXCEL, U-EXCEED and U-ENDURE trials.

In this Healio video, Edward V. Loftus Jr., MD, previews this month’s Healio Exclusive, in which experts tout the positive attributes of Janus kinase inhibitors for inflammatory bowel disease and discuss their role in the treatment landscape.

The FDA has granted breakthrough therapy designation to Boehringer Ingelheim’s survodutide for the treatment of adult patients with noncirrhotic metabolic dysfunction-associated steatohepatitis and moderate or advanced fibrosis.

Significant variations in global rates of infection, culture-positivity and drug resistance serve as a “call to action” to streamline antibiotic use and improve outcomes among inpatients with cirrhosis, according to researchers.

Delays in cancer registration may have underestimated 10-year colorectal cancer risk reductions by up to 75% in the NordICC trial, with researchers warning that study estimates on screening colonoscopy should be “interpreted with caution.”

The FDA has approved subcutaneous and IV formulations of the Stelara biosimilar Otulfi for Crohn’s disease, ulcerative colitis and all other indications approved for the reference product, according to a press release from Fresenius Kabi.

Superabsorbent polymer beads that are often used as toys or decorations can cause bowel obstructions in young children, which may require surgery, according to research presented at the AAP National Conference & Exhibition.