VIDEO: Total bile acids, MMP-7 show ‘amazing promise’ in prognosis of biliary atresia
In this video, Ahmad Anouti, MD, a pediatric resident at UT Southwestern Medical Center, discusses the importance of serum values as prognostic indicators in biliary atresia, as well as identifying specific time points for follow-up.
To identify serum predictors of native liver survival among patients after hepatoportoenterostomy, Anouti and colleagues conducted a systematic review and meta-analysis of 30 studies, the results of which were presented at The Liver Meeting. They assessed patients as successful or nonfunctioning at follow-up intervals of 1 to 3 months, 4 to 12 months, 1 to 4 years and more than 5 years.
According to Anouti, elevations in total bilirubin, alanine aminotransferase and gamma-glutamyl transferase were significant, as were total bilirubin levels less than 1 mg/dL at 1 year.
“I think the most important finding is that values like total bile acids and MMP-7 show amazing promise and, I personally believe, even hold better prognostic value than what we have currently,” Anouti said.
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Anouti A, et al. Serum values in biliary atresia patients as indicators for native liver survival: A systematic review and meta-analysis. Presented at: The Liver Meeting; Nov. 15-19, 2024; San Diego (hybrid meeting).
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