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Is intensive weight loss harmful in some patients? Read the week’s top stories in endocrinology

A post hoc analysis of the Look AHEAD trial showed that intensive weight loss interventions can reduce CV events in some patients with type 2 diabetes, but they may also have a detrimental effect in others. Another recent study that found most patients who had bariatric surgery had at least one nutritional deficiency years later, even after taking supplements.

These and more were among the recent top stories in endocrinology.

Intensive weight loss fails to reduce CV risk among certain patients with type 2 diabetes

Cardiovascular event risk for those with overweight or obesity can either be lowered or heightened with intensive lifestyle interventions depending on certain factors, according to findings published in Diabetes Care. Read more.

Supplements may not prevent long-term nutritional deficiency after bariatric surgery

In a cohort of adults who underwent bariatric surgery, 73% had at least one nutritional deficiency 5 years later even though 73% reported taking a dietary supplement, according to findings published in Bariatric Surgical Practice and Patient Care. Read more.

Novo Nordisk announces half-price, authorized generic insulins

Novo Nordisk announced that it will offer “authorized generic” versions of its insulin aspart and insulin aspart mix beginning in January 2020, with the follow-on brands priced 50% lower than the current list price of its branded versions of the drugs, according to an industry press release. Read more.

SGLT2 inhibitors offer ‘clear and powerful reductions’ for major kidney outcomes in type 2 diabetes

A meta-analysis of four recent cardiovascular and kidney outcomes trials assessing the use of SGLT2 inhibitors among patients with type 2 diabetes suggests that the drug class offers nephroprotective benefits across all levels of kidney function, regardless of albuminuria status, according to findings published in The Lancet Diabetes & Endocrinology. Read more.

Antithyroid medications provide ‘disappointing’ results for treating Graves’ disease

Radioactive iodine therapy and thyroid surgery may be more effective than antithyroid medications in helping adults with Graves’ hyperthyroidism achieve remission, according to findings published in Thyroid. Read more.