Weight Loss
Postoperative weight loss with anti-obesity medication may decrease risk of revision TJA
Published results showed patients with obesity who took anti-obesity medications and had postoperative weight loss within 1 year after total joint arthroplasty may be at significantly decreased risk for revision at 5 and 10 years.
Unintended weight loss before kidney transplant evaluation tied to lower listing odds
Unintentional weight loss prior to kidney transplant evaluation may be linked to lower listing odds and higher waitlist mortality for frail patients with obesity, a study found.
Carbonated water may produce some weight loss but is not a ‘standalone solution’
Carbonated water may indirectly produce weight loss by boosting metabolism and blood glucose uptake, according to a brief report in BMJ Nutrition, Prevention & Health.
Top in endocrinology: Metformin plus Mediterranean diet; lean mass loss with GLP-1s
A randomized controlled trial demonstrated a significantly reduced incidence of type 2 diabetes among individuals with metabolic syndrome who received daily metformin with or without a Mediterranean diet intervention.
About 31% of weight lost by adults during GLP-1 therapy comes from lean mass
Lean mass constituted 30.8% of total body weight lost for adults who received a GLP-1 drug during a randomized controlled trial, according to findings published in Obesity.
Novel obesity drug induces up to 22% weight loss with no safety concerns
A novel GLP-1 and amylin receptor agonist featured a safety profile similar to other incretin-based therapies and conferred a significant weight reduction compared with placebo, according to top-line results from a phase 1b/2a trial.
STEP UP: High-dose semaglutide led to 21% weight loss for adults with obesity
Adults with obesity receiving once-weekly semaglutide 7.2 mg lost a higher proportion of their body weight at 72 weeks than adults receiving semaglutide 2.4 mg, according to top-line results from the STEP UP phase 3b trial.
Sculptra, hyaluronic filler regimen corrects facial sagging from GLP-1-induced weight loss
New data suggest Restylane Lyft or Contour in combination with Sculptra corrects contour deficiencies in patients experiencing facial volume loss following medication-driven weight loss, according to a Galderma press release.
GLP-1s reduce weight, with investigational therapies potentially more effective
A dozen GLP-1 receptor agonists and coagonists demonstrated effectiveness for weight loss in adults with obesity and without diabetes, a systematic review published in Annals of Internal Medicine showed.
Novel drug confers weight loss of up to 20% at 1 year in phase 2 study
Maridebart cafraglutide, a novel injectable GLP-1 receptor agonist/GIP receptor antagonist, reduced body weight by up to approximately 20% at 1 year in patients with overweight or obesity without a weight loss plateau, according to a presentation.