Sodium-Glucose Transporter 2 Inhibitor

The use of GLP-1 receptor agonists corresponded with a lower risk for depression among older adults with type 2 diabetes compared with dipeptidyl peptidase 4 inhibitors, results of a target trial emulation study suggested.

CHICAGO — Use of an SGLT2 inhibitor or GLP-1 receptor agonist after stroke may improve mortality and lower subsequent risk for heart attack and another stroke, a speaker reported.

BOSTON — Fewer patients with pulmonary arterial hypertension died at three time points with use of a sodium-glucose cotransporter-2 inhibitor, according to data presented at the CHEST Annual Meeting.

The use of sodium-glucose cotransporter 2 inhibitors reduced the risk for multiple neurodegenerative diseases in adults with type 2 diabetes, according to study results published in Neurology.

Sodium-glucose cotransporter-2 inhibitors showed similar hepatic effectiveness to glucagon-like peptide-1 receptor agonists, especially among women and younger patients, in metabolic dysfunction-associated steatotic liver disease.

GLP-1 receptor agonist use on top of SGLT2 inhibition in patients with HF with preserved ejection fraction, type 2 diabetes and obesity was associated with reduced risk for adverse events vs. SGLT2 inhibition alone, researchers reported.

SGLT2 inhibitors were associated with similar renal and CV outcomes vs. GLP-1 receptor agonists for patients with diabetes, regardless of chronic kidney disease status, researchers reported.

In an analysis of more than 3 million U.S. adults, most patients with a class 1a recommendation for SGLT2 inhibitors were not prescribed them, researchers reported in the Journal of the American College of Cardiology.

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PHILADELPHIA — Early, cost-effective screening may predict and prevent incident heart failure events for patients with diabetes and no prior heart disease, a speaker reported.