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Therapeutics/Diagnostics News
Mebeverine not superior to placebo in pediatric IBS; active drug labeling improved efficacy
WASHINGTON — Mebeverine was not superior to placebo for the treatment of pediatric irritable bowel syndrome and functional abdominal pain, although active drug labeling significantly improved treatment success, researchers reported.
‘Unexpectedly high’ placebo response derails darvadstrocel for Crohn’s perianal fistulas
WASHINGTON — Darvadstrocel demonstrated “no statistically significant or clinically meaningful” benefit vs. placebo for complex perianal fistulas and Crohn’s disease, according to ADMIRE-CD II trial data presented at Digestive Disease Week.
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TRIUMPH: 58% of acute severe UC patients responded ‘within 2 days’ of starting Xeljanz
WASHINGTON — Nearly 60% of patients with acute severe ulcerative colitis responded to Xeljanz 10 mg twice daily by day 7, with one-third of patients in steroid-free remission by 6 months, according to interim analysis data presented here.
Noninvasive tests identify candidates for Rezdiffra, predict response in patients with MASH
WASHINGTON — Researchers have determined that several noninvasive tests could help identify candidates for treatment with Rezdiffra, as well as predict response, in metabolic dysfunction-associated steatohepatitis.
Survodutide upholds ‘promising’ reduced liver fat, fibrosis biomarkers in MASH at 28 weeks
WASHINGTON — Survodutide sustained improvement in liver fat content, liver enzymes and fibrosis biomarkers in patients with metabolic dysfunction-associated steatohepatitis at 28 weeks, according to a late-breaking abstract presented here.
Vonoprazan reduces heartburn symptoms as early as day 1 in nonerosive reflux disease
WASHINGTON — Vonoprazan effectively relieved heartburn symptoms in patients with nonerosive reflux disease as early as day 1 of treatment, with results persisting after a 4-week placebo-controlled period through 20 weeks, according to data.
VIDEO: Real-world data confirm Rebyota’s ‘consistent’ efficacy in recurrent C. difficile
WASHINGTON — In a Healio video exclusive, Paul Feuerstadt, MD, FACG, AGAF, discusses real-world results for Rebyota as a treatment of recurrent Clostridioides difficile infection, which were presented at Digestive Disease Week.
Blood-based screening test detects CRC with nearly 80% sensitivity in average-risk adults
WASHINGTON — A blood-based screening test detected colorectal cancer with a sensitivity of 79.2% and a specificity of 91.5% among average-risk adults aged 45 to 85 years, according to research presented at Digestive Disease Week.
SEQUENCE: Skyrizi outperforms for Crohn’s remission; Stelara ‘still remains on the table’
WASHINGTON — Although a greater number of patients with Crohn’s disease who failed anti-TNF therapy achieved biologic remission with Skyrizi vs. Stelara, choosing between the two therapies “still remains on the table,” a researcher noted.
Statin use linked to ‘sharp 86% risk reduction’ for primary sclerosing cholangitis in IBD
WASHINGTON — Statin use was associated with up to a 90% risk reduction for new-onset primary sclerosing cholangitis among patients with inflammatory bowel disease, according to data presented at Digestive Disease Week.
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Headline News
Burnout, withdrawal remain ‘alarmingly high’ among physicians and residents
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Over one-third of adults not planning on receiving recommended vaccines this fall
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September 19, 20242 min read
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Headline News
Burnout, withdrawal remain ‘alarmingly high’ among physicians and residents
September 17, 20242 min read -
Headline News
Over one-third of adults not planning on receiving recommended vaccines this fall
September 18, 20242 min read -
Headline News
Popular home BP devices unable to provide accurate readings for millions due to sizing
September 19, 20242 min read