Improving Vaccination Uptake
Vaccine Hesitancy and Misinformation
Over the past few decades, vaccine hesitancy has become increasingly prevalent globally. The World Health Organization (WHO) declared vaccine hesitancy one of its top 10 global health threats in 2019. Generally, reasons for vaccine hesitancy fall into three main categories:
- a lack of confidence in the effectiveness and safety of vaccines, or a lack of trust in the healthcare system and policymakers;
- complacency (i.e., a perceived low risk of contracting vaccine-preventable diseases), and
- a lack of convenience (issues related to the availability, accessibility and appeal of immunization services, including factors such as time, location, language and cultural context).
In addition to the general risk factors for vaccine hesitancy, measles vaccine uptake was negatively impacted by the publication in 1998 of a paper by the gastroenterologist Andrew Wakefield that made the claim that the measles, mumps, and rubella (MMR) vaccine potentially causes…
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Vaccine Hesitancy and Misinformation
Over the past few decades, vaccine hesitancy has become increasingly prevalent globally. The World Health Organization (WHO) declared vaccine hesitancy one of its top 10 global health threats in 2019. Generally, reasons for vaccine hesitancy fall into three main categories:
- a lack of confidence in the effectiveness and safety of vaccines, or a lack of trust in the healthcare system and policymakers;
- complacency (i.e., a perceived low risk of contracting vaccine-preventable diseases), and
- a lack of convenience (issues related to the availability, accessibility and appeal of immunization services, including factors such as time, location, language and cultural context).
In addition to the general risk factors for vaccine hesitancy, measles vaccine uptake was negatively impacted by the publication in 1998 of a paper by the gastroenterologist Andrew Wakefield that made the claim that the measles, mumps, and rubella (MMR) vaccine potentially causes inflammatory bowel disease, and, secondarily, autism. No evidence for a link between the MMR vaccine and autism was uncovered by numerous studies. To take just one example, a retrospective cohort study of all 537,000 children born in Denmark between 1991 and 1998 (of whom 440,000 received the MMR vaccine) found no link between autism and MMR vaccination. The 1998 paper was thus found to be incorrect in its conclusions, and further investigation revealed it to be fraudulent, containing falsified patient records. Although Wakefield’s paper was retracted in 2010, fear of autism remains the most common reason for MMR vaccine hesitancy.
An American Academy of Pediatrics (AAP) clinical report on strategies for improving vaccine uptake suggested a categorization of parents into five classes on the basis of vaccine hesitancy, including:
- Immunization supporters (who actively seek out immunization for their children)
- Go along to get along parents (who do not question vaccination)
- Cautious acceptors (who have some reservations but generally vaccinate their children)
- Fence-sitters (who have significant concerns about vaccination)
- Refusers (who are strongly against vaccination).
An effective strategy to overcome vaccine hesitancy must contain elements that target “fence-sitters” and “refusers”. An incentive-based approach, spreading of awareness and education and technology-based health literacy are strategies to be implemented (Figure 6-1). A variety of resources may be employed in patient education, including lectures, videos, podcasts, online modules, role-play simulations and others.
The AAP suggests the following strategies to help overcome vaccine hesitancy:
- Strong recommendations: Clinicians should provide a strong, confident recommendation for vaccines using a presumptive format (i.e., assume that the parent will vaccinate)
- Early conversations: Vaccine discussions should be initiated during the prenatal period
- Motivational interviewing: A patient-centered interviewing technique that uses open-ended questions, affirmation of parent engagement in the decision-making process, reflection on reasons for hesitancy, and other strategies to alleviate defensiveness.
Other organizations have suggested similar approaches. The FrameWorks Institute proposed the following five strategies to improve childhood vaccination:
- Presenting the benefits of vaccination as a common good
- Talking about improving vaccination access as a preventive public health measure
- Focusing the benefits vaccines have on the long-term health and wellbeing of children and adolescents
- Use the metaphor of software updates to explain vaccination as a form of immune system update
- Use the metaphor of literacy to explain that the immune system learns to respond to pathogens via vaccination.
Additionally, community health training can address specific concerns and misinformation about vaccines. Engaging with communities to understand their specific concerns and working collaboratively can build trust and acceptance. For this, training healthcare providers to communicate effectively about vaccines is crucial. Educators may have to “compete” with family members, friends, religious and political leaders and celebrity “antivaxxers” who may present an opposing message that seems all the more concerning because of fear generated by misinformation. Additionally, improving the accessibility and convenience of vaccination services can further reduce vaccination hesitancy. Lastly, implementing policies that encourage vaccination, such as school-entry requirements, can increase vaccination rates. Policies should also support efforts to reduce misinformation and promote vaccine benefits.
The Role of Public Health Initiatives in Measles Eradication Efforts
Public health initiatives play a crucial role in addressing vaccine hesitancy through various strategic approaches. The WHO has led multiple initiatives, including the development of a Global Vaccine Action Plan aimed at strengthening immunization systems and promoting vaccine confidence worldwide. This plan includes measures to improve communication strategies, enhance vaccine delivery and ensure everyone has equal access to vaccines. Additionally, the WHO has worked on improving monitoring systems to better understand the reasons behind vaccine hesitancy and to tailor interventions accordingly. Besides prevention, public health initiatives are responsible for adequate response to disease outbreaks. Strategies used to limit measles spread in elimination settings include assembly of an outbreak control committee, isolation of measles cases while infectious, exclusion and quarantining of individuals without evidence of immunity, vaccination of susceptible individuals, use of immunoglobulin to prevent measles in exposed susceptible high-risk persons, and maintaining laboratory proficiency for confirmation of measles; see Assessment and Treatment and Prevention and Control for more information.
References
- DeStefano F, Shimabukuro TT. The MMR Vaccine and Autism. Annu Rev Virol. 2019;6(1):585-600.
- Eriksen M, Frandsen T. The impact of patient, intervention, comparison, outcome (PICO) as a search strategy tool on literature search quality: a systematic review. J Med Lib Assoc. 2018;106(4):420–31.
- Gastañaduy PA, Banerjee E, DeBolt C, et al. Public health responses during measles outbreaks in elimination settings: Strategies and challenges. Hum Vacc Immunother. 2018;14(9):2222-2238.
- Gastañaduy PA, Goodson JL, Panagiotakopoulos L, et al. Measles in the 21st Century: Progress Toward Achieving and Sustaining Elimination. J Infect Dis. 2021;224(4):S420-S428.
- Godlee F, Smith J, Marcovitch H. Wakefield's article linking MMR vaccine and autism was fraudulent. BMJ. 2011;342:c7452.
- Hou Z, Tong Y, Du F, et al. Assessing COVID-19 Vaccine Hesitancy, Confidence, and Public Engagement: A Global Social Listening Study. J Med Internet Res. 2021;23(6):e27632.
- Lip A, Pateman M, Fullerton MM, et al. Vaccine hesitancy educational tools for healthcare providers and trainees: A scoping review. Vaccine. 2023;41(1):23-35.
- Madsen KM, Hviid A, Vestergaard M, et al. A population-based study of measles, mumps, and rubella vaccination and autism. N Engl J Med. 2002;347(19):1477-1482.
- Novilla MLB, Goates MC, Redelfs AH, et al. Why Parents Say No to Having Their Children Vaccinated against Measles: A Systematic Review of the Social Determinants of Parental Perceptions on MMR Vaccine Hesitancy. Vaccines (Basel). 2023;11(5):926.
- Nuwarda RF, Ramzan I, Weekes L, Kayser V. Vaccine Hesitancy: Contemporary Issues and Historical Background. Vaccines. 2022;10(10):1595.
- O'Leary ST, Opel DJ, Cataldi JR, et al. Strategies for Improving Vaccine Communication and Uptake. Pediatrics. 2024;153(3):e2023065483.
- Reframing the Conversation about Child and Adolescent Vaccinations. www.frameworksinstitute.org. https://www.frameworksinstitute.org/publication/reframing-the-conversation-about-child-and-adolescent-vaccinations/. Accessed August 15, 2024.
- Shen SC, Dubey V. Addressing vaccine hesitancy: Clinical guidance for primary care physicians working with parents. Can Fam Physician. 2019;65(3):175-181.
- Singh P, Dhalaria P, Kashyap S, et al. Strategies to overcome vaccine hesitancy: a systematic review. Syst Rev. 2022;11(1):78.
- Strategic Advisory Group of Experts on Immunization, World Health Organization. Report of the SAGE Working Group on Vaccine Hesitancy. www.who.int.myaccess.library.utoronto.ca/immunization/sage/meetings/2014/october/1_Report_WORKING_GROUP_vaccine_hesitancy_final.pdf. Accessed August 15, 2024.
- Vassantachart JM, Yeo AH, Vassantachart AY, Jacob SE, Golkar L. Art of prevention: The importance of measles recognition and vaccination. Int J Womens Dermatol. 2019;6(2):89-93.
- Wang R, Jing W, Liu M, Liu J. Trends of the Global, Regional, and National Incidence of Measles, Vaccine Coverage, and Risk Factors in 204 Countries From 1990 to 2019. Front Med. 2022;8:798031.
- WHO. Ten Threats to Global Health in 2019. https://www.who.int/news-room/spotlight/ten-threats-toglobal-health-in-2019. Accessed August 15, 2024.
- World Health Organization. Global vaccine action plan 2011-2020. https://www.who.int/publications/i/item/global-vaccine-action-plan-2011-2020. Accessed August 15, 2024.