Top in endocrinology: Weight loss with high-carb diet; GLP-1s for kidney, heart disease

Results of a randomized study revealed that adults with obesity assigned to a low-energy diet with low-, medium- or high-carbohydrate intake all achieved ketosis and weight loss without the expected increase in hunger.

“Maximizing carbohydrate intake while preventing increased hunger ratings will allow those seeking weight loss to eat more micronutrient-rich, carbohydrate-containing foods that are beneficial for health, which is likely to improve dietary adherence and weight loss outcomes,” Jessica A. Roekenes, a PhD candidate in the department of clinical and molecular medicine at Norwegian University of Science and Technology in Trondheim, Norway, and colleagues wrote in Obesity.

It was the top story in endocrinology last week.

In another top story, researchers found that GLP-1 receptor agonists lowered composite kidney outcomes, kidney failure, major adverse cardiovascular events and all-cause mortality vs. placebo among patients with type 2 diabetes.

Read these and more top stories in endocrinology below:

Severe carbohydrate restriction not necessary for ketosis, weight loss in low-energy diets

Low-energy diets that included up to 130 g per day of carbohydrates still induced weight loss in association with ketosis without the expected increase in hunger among adults with obesity, according to a study published in Obesity. Read more.

GLP-1s ‘could play an important role’ in slowing kidney, heart disease progression

GLP-1 receptor agonists improved clinical outcomes related to kidney and heart health while lowering mortality rates for individuals with diabetes, chronic kidney disease or preexisting cardiovascular disease with overweight or obesity. Read more.

Personality traits, lifestyle behaviors affect CVD risk in patients with type 2 diabetes

The personality traits of patients with type 2 diabetes, particularly diligence, may impact their risk for cardiovascular disease, according to findings published in BMJ Open Diabetes Research & Care. Read more.

VIDEO: Update on anticipated standards document for obesity treatment

In this Healio video exclusive, Jamy D. Ard, MD, FTOS, provided a 1-year update on The Obesity Society’s multisociety initiative to develop standards of care for obesity. Watch here.

Insulin resistance, hyperinsulinemia may predict aortic stenosis in men

Hyperinsulinemia and/or insulin resistance biomarkers — such as fasting, plasma insulin and proinsulin — predicted aortic stenosis, independent of other cardiovascular risk factors, according to study results published in Annals of Medicine. Read more.