VIDEO: Expert recaps new FMT data presented at DDW

SAN DIEGO — In this exclusive video from DDW, Colleen R. Kelly, MD, from Brown University and the Center for Women’s GI Medicine in Providence, Rhode Island, discusses two abstracts on fecal microbiota transplantation she found to be particularly significant.

The first abstract reported results from more than 1,400 patients with recurrent or refractory Clostridium difficile infection who were treated with FMT from the international public stool bank OpenBiome. These data showed the donor material was highly effective, and that efficacy varied by route of infusion, with superior efficacy attributed to lower vs. upper gastrointestinal delivery.

“I think this was exciting because it gave us a lot of real-world efficacy data from a large number of patients,” Kelly said.

The second abstract reported results from the FOCUS study, which showed that intensive FMT induced clinical and endoscopic response in patients with resistant ulcerative colitis.

“This is another example of fecal transplant healing diseases associated with alterations in gut bacteria, or dysbiosis,” Kelly said. “It’s certainly not ready for prime time at this point, but ... this study combined with the Moayyedi study, which was published last year, give a signal of efficacy in ulcerative colitis, and I think further studies are sure to help us there.”

References:

O’Brien K, et al. Abstract #Su1737. Presented at: Digestive Disease Week; May 21-24, 2016; San Diego.

Paramsothy S, et al. Abstract #600. Presented at: Digestive Disease Week; May 21-24, 2016; San Diego.

Disclosures: Kelly reports consulting for Seres Health and research/grant support and other financial benefits from Assembly Biosciences.