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Allium vegetables, garlic supplements did not reduce CRC risk
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High intake of allium vegetables or garlic supplements were not found to reduce the risk for colorectal cancer, according to new research data.
In 2013, researchers performed a meta-analysis of prospective studies to provide a comprehensive assessment of associations between intake of allium vegetables, garlic supplements and risk for CRC. Eight studies included in the meta-analysis focused on allium vegetables and involved 5,458 patients with CRC and 7,125,067 person-years of follow-up, and five studies focused on garlic supplements and involved 2,685 patients and 2,304,439 person-years of follow-up.
Pooled analysis showed no association between high intake of allium vegetables and risk for CRC (RR=1.06; 95% CI, 0.96-1.17), but garlic supplements were associated with increased risk for CRC (RR=1.18; 95% CI, 1.02-1.36). Intake of allium vegetables did not correspond to CRC risk (P for nonlinear=.24; P for linear=.2). Subgroup analysis revealed a slightly increased risk for colon cancer among women with higher allium vegetable intake (RR=1.23; 95% CI, 1.01-1.5).
“In summary, our meta-analysis found that allium vegetable consumption and garlic supplements do not reduce the risk of CRC,” the researchers concluded. “Randomized controlled trials or well-designed cohort studies are warranted to confirm the adverse effects of garlic supplements.”
Disclosure: The researchers report no relevant financial disclosures.
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