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Small bowel cancer incidence doubled in the UK

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PHILADELPHIA — The incidence rate of small bowel cancer in the United Kingdom doubled during the past 2 decades, with little improvement in mortality rates, according to data presented at the ACG Annual Scientific Meeting.

“[Using the National UK Association of Cancer registries database], we retrospectively reviewed and carried out a descriptive analysis of [small bowel cancer] incidence rates with respect to gender, age, ethnicity, socioeconomic status and mortality rates,” Lolita Chan, BSc, MBChB, MRCP, of the Central Manchester University Hospitals NHS Foundation, United Kingdom, said during her presentation. 

The National UK Association of Cancer Registries database identified 11,872 people diagnosed with small bowel cancer (SBC) between 1991 and 2009. Of those patients, 53.6% were male and diagnosed at a mean age of 67 years. Incidence of SBC increased from 0.71 to 1.51 per 100,000 from 1991 to 2009. The mortality rate increased as SBC incidence increased, but at a “lesser extent,” according to the research.

The most common place SBC was found was at the duodenum (57.5%), and the incidence rate tripled (0.24 to 0.63 per 100,000) over time compared with the jejunum (12.1%, 0.07 to 0.11 per 100,000) and ileum (30.4%; 0.14 to 0.33 per 100,000), which doubled over time. 

SBC incidence was 1.5 and three times greater among the white population compared with black and Asian populations, respectively.

 “UK SBC incidence has increased over the last 2 decades with little improvement in mortality, reflecting improved radiological imaging and invasive diagnostics,” Chan said during her presentation. “Further studies are required to gain more comprehensive understanding of the natural history, environmental and genetic predisposition of SBCs, and looking very much forward, this may then allow us to have the potential patient stratification, more efficient diagnosis, more options in terms of treatment and thus improving its poor prognosis.”

For more information

Chan L. Abstract 57. Presented at: ACG Annual Scientific Meeting, Oct. 17-22, 2014; Philadelphia.

Disclosure: Relevant financial disclosures were not provided by the researchers.