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Family history of IBD present in 12% of patients with UC
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Twelve percent of patients with ulcerative colitis had a family history of inflammatory bowel disease, and this history more frequently was manifested as ulcerative colitis than as Crohn’s disease in a recent study.
In a systematic review and meta-analysis, investigators included 71 studies with 86,824 patients from the PubMed database pertaining to the prevalence of family history of IBD among UC patients. The researchers established definitions of family history, study type, and subtypes of family history prevalence.
They also culled information about disease outcomes, including age at UC diagnosis, disease location, surgery, and extraintestinal symptoms. Random effects models were used to calculate pooled prevalence estimates.
The researchers found that among UC patients, the prevalence of IBD family history was 12% (95% CI, 11%-13%). Among these patients, there was a greater prevalence of UC family history (9%; 22 studies) than Crohn’s disease family history (2%; 18 studies). There also was a greater prevalence of IBD family history when patients were aged younger than 18 years (15%; 95% CI, 11-20%; 13 studies). Patients with IBD family history did not differ from those without family history in terms of disease location, surgical need, or extraintestinal disease manifestation. The researchers cautioned, however, that only a small number of the studies reported on these outcomes.
“Overall, 12% of ulcerative colitis patients have a family history of inflammatory bowel disease and were more likely to have a family history of ulcerative colitis than Crohn’s disease,” the researchers concluded. “Pediatric-onset ulcerative colitis patients were more likely to have a family history of inflammatory bowel disease.”
Disclosure: The researchers report no relevant financial disclosures.
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