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Celiac disease increased fourfold, in contrast with 4% decrease in dermatitis herpetiformis
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Incidence of celiac disease increased fourfold in the UK, contrasting with a 4% annual decrease in dermatitis herpetiformis cases during the same 22-year study period, according to new data.
Using the Clinical Practice Research Datalink (1990-2011), researchers identified patients with celiac disease (CD; n=9,087) or dermatitis herpetiformis (DH; n=809). Age, sex, year, and region of residence were factored into calculations of incidence rates and prevalence, with incident rate ratios adjusted for age, sex and region using Poisson regression.
The incident rate of CD increased from 5.2 per 100,000 (95% CI, 3.8-6.8) to 19.1 per 100,000 person-years (95% CI, 17.8-20.5; IRR=3.6; 95% CI, 2.7-4.8).
During the same period, the DH incidence rate decreased from 1.8 per 100,000 person-years to 0.8 per 100,000 person-years (average annual IRR=0.96; 95% CI, 0.94-0.97).
Researchers found large regional variations in prevalence for CD, but not for DH. They reported an absolute incidence of CD in Northern Ireland at 22.3 per 100,000 person-years compared with 10 per 100,000 person-years in London.
“These findings raise the possibility that inequality in the diagnostic pathways across time, place, and person exist in the United Kingdom, given that it is thought that most sections of society appear to have a reasonably similar background risk of having CD,” the investigators concluded.
Disclosure: This project was funded by CORE/Coeliac UK.
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