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Study urges colonoscopic surveillance after adenoma removal
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The risk of developing colorectal cancer remained high after adenoma removal but could be reduced by follow-up colonoscopy, a study found.
“In routine practice, the risk of colorectal cancer after adenoma removal remains high and depends both on initial adenoma features and on colonoscopy surveillance practices,” the researchers said. “Gastroenterologists should encourage patients to comply with long-term colonoscopic surveillance.”
Researchers in France reviewed data from 5,779 individuals first diagnosed with colorectal ademona between 1990 and 1999. Initial data and follow-up data through 2003 were used to calculate cumulative probabilities of colorectal cancer after adenoma removal.
After a median follow-up of 7.7 years, 87 invasive colorectal cancers were diagnosed, compared to 69 expected cases. The overall standardized incidence ratio (SIR) compared with the general population was 1.26 (95% CI, 1.01-1.56).
Risk of colorectal cancer depended on initial adenoma characteristics (SIR=2.23; 95% CI, 1.67-2.92) for advanced adenomas. For non-advanced adenomas, the SIR was 0.68 (95% CI, 0.44-0.99).
In advanced adenomas with colonoscopic follow-up, SIR was 1.10 (95% CI, 0.62-1.82). In those without colonoscopic follow-up, SIR was 4.26 (95% CI, 2.89-6.04).
Disclosure: The researchers report no relevant financial disclosures.