History -- Part 2

• 4/17/15: Right robotic assisted laparoscopic radical nephroureterectomy
• Pathology
• Renal pelvis – high grade, urothelial carcinoma with lamina propria invasion, negative margins, pT1Nx
• Mid ureter – high grade, urothelial carcinoma with lamina propria invasion, negative margins, pT1Nx
• Distal ureter – high grade, urothelial carcinoma with lamina propria invasion, negative margins, pT1Nx
• 8/18/15: CT A/P with new right pelvic side wall adenopathy, worrisome for metastatic disease.
• 11/24/15: CT A/P with increasing pelvic mass, worrisome for recurrence as well as new pulmonary nodule.
• 12/7/15: Biopsy of right pelvic sidewall mass confirms metastatic urothelial carcinoma.
• December 2015-March 2016: Received palliative gemcitabine and carboplatin x4 cycles followed by progression
• Received weekly docetaxel x1 cycle followed by clinical and radiographic progression.
• Received palliative radiotherapy to bilateral acetabular regions, completed May 2016
• Tumor molecular testing identified FGFR3 R248C mutation.