Virtual Molecular Tumor Board

Atrium Health
Presented by: Dr. Julie Fisher
Patient: Metastatic breast cancer

Initial Diagnosis and Treatment

A 55-year-old Caucasian woman noted a palpable lump in her left breast in August 2008.

• Diagnostic breast imaging revealed a 1.6 cm x 1.2 cm x 1.0 cm spiculated mass corresponding to the area of palpable concern
• Ultrasound-guided core biopsy showed poorly differentiated invasive ductal carcinoma: ER+, PR+, HER-2-Neu 2+ by immunohistochemistry (equivocal) and negative by FISH (ratio: 1.46)
• September 2008: Initiated dose-dense doxorubicin/cyclophosphamide
• Patient was found to have metastasis to the lung and liver after two cycles