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Healio spoke with Delamo I. Bekele, MBBS, clinical rheumatologist and assistant professor of medicine at Mayo Clinic, and Devon Charlton, MD, rheumatologist at University of Pittsburgh Medical Center, about who is most likely to be diagnosed, considerations when selecting the appropriate treatment for a patient, when to move on to a new treatment if there is not enough response, efficacy and side effects of biologic treatments and the role patient lifestyle and preference plays into treatment decisions.