Ankylosing Spondylitis Central

• Many people with axial spondylarthritis progress to having some spinal fusion, known as ankylosing spondylitis.
• The general onset of AS commonly occurs in individuals between the ages of 17 and 45 but can also affect children and the elderly.
• Recent estimates show that the prevalence of AS in the United States is about 0.2-0.5%.
• A clear sign of AS is a change in the sacroiliac joints at the base of the low back.
• AS can cause episodes of acute iritis in up to 40 percent of patients.
• AS is not a purely genetic disease, and genetic and environmental factors both likely play a part in determining the risk of its development.
• The most common extraarticular manifestations of AS are inflammatory bowel disease, acute anterior uveitis and psoriasis.
• Patients with AS are at increased risk of atlantoaxial subluxation and spinal cord injury.

References

• https://www.hopkinsarthritis.org/arthritis-info/ankylosing-spondylitis/
• https://stanfordhealthcare.org/medical-conditions/bones-joints-and-muscles/ankylosing-spondylitis/diagnosis.html
• https://spondylitis.org/about-spondylitis/types-of-spondylitis/ankylosing-spondylitis/
• https://my.clevelandclinic.org/health/diseases/16595-ankylosing-spondylitis-as/management-and-treatment
• https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Spondyloarthritis
• https://ghr.nlm.nih.gov/condition/ankylosing-spondylitis
• https://www.ncbi.nlm.nih.gov/books/NBK470173