Top in endocrinology: PFAS linked to offspring BMI; SGLT2 inhibitors may lower cancer risk
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A recent study found an increased risk for overweight and obesity in the offspring of women exposed to per- and polyfluoroalkyl substances during pregnancy.
“Although the effect sizes observed in the present analysis were subtle, they may have large population level effects due to the ubiquity of PFAS exposure and high prevalence of pediatric obesity and overweight,” Yun Liu, PhD, a postdoctoral research associate in the department of epidemiology at Brown University School of Public Health, and Joseph M. Braun, PhD, a professor in the department of epidemiology at Brown University School of Public Health, told Healio.
It was the top story in endocrinology last week.
Another top story covered new research indicating that patients with diabetes who use SGLT2 inhibitors had lower risks for developing cancer than those who do not. Researchers further reported that cancer risk decreased with longer durations of SGLT2 inhibitor use.
“The observational study is hard to address the detailed mechanism underling the observation. Nonetheless, the trend is clear and based upon a well validated nationwide dataset. Further prospective mechanism exploring research is necessary,” they wrote.
Read these and more top stories in endocrinology below:
Pregnant women exposed to higher levels of PFAS more likely to have children with high BMI
Women exposed to higher concentrations of per- and polyfluoroalkyl substances during pregnancy had children with higher BMI z scores and greater risks for overweight or obesity at age 2 to 5 years, according to study data. Read more.
SGLT2 inhibitors may reduce cancer risks among adults with diabetes
Adults with diabetes who use SGLT2 inhibitors had lower risks for developing most types of cancer compared with nonusers, though the risk for pancreatic cancer was higher among SGLT2 users, according to data from researchers in Taiwan. Read more.
Low vitamin D levels observed among adults with long COVID 6 months post-infection
Adults diagnosed with COVID-19 who had long COVID at a 6-month follow-up had lower vitamin D levels than COVID-19 survivors without long COVID, according to data published in The Journal of Clinical Endocrinology & Metabolism. Read more.
Adults hospitalized with COVID-19 have lower thyroglobulin levels with glucocorticoid use
Thyroglobulin levels differed by glucocorticoid use, but not by thyroid function, among a cohort of adults hospitalized for COVID-19, according to findings published in Frontiers in Endocrinology. Read more.
Recurrence uncommon for adults with medullary thyroid microcarcinoma
In a small group of adults diagnosed with medullary thyroid microcarcinoma, few had disease recurrence or died during more than 6 years of follow-up, according to findings from an Australian database. Read more.