Top in endocrinology: Time-restricted eating; drivers of atherosclerotic CVD

Time-restricted eating was associated with improvements in cardiometabolic markers among adults with normal weight and overweight, according to a study published in The Journal of Clinical Endocrinology & Metabolism.

In particular, time-restricted eating with 16 hours of fasting and an 8-hour eating window was “an effective approach to improve the metabolic state of nonobese subjects,” study author Fang Hu, PhD, told Healio. It was the top story in endocrinology last week.

Another top story was about a presentation on drivers of atherosclerotic CVD at the World Congress on Insulin Resistance, Diabetes and Cardiovascular Disease. Ralph A. DeFronzo, MD, said that underlying insulin resistance and compensatory hyperinsulinemia drive atherosclerotic CVD before patients are diagnosed with type 2 diabetes, and early detection measures are necessary to mitigate risk.

Read these and more top stories in endocrinology below:

Time-restricted eating improves cardiometabolic markers among most adults

Adults partaking in time-restricted eating have greater decreases in body weight, fat mass, fasting blood glucose and other cardiometabolic markers compared with controls, according to findings from a systematic review and meta-analysis. Read more.

Insulin resistance, hyperinsulinemia primary drivers of atherosclerotic CVD

Underlying insulin resistance and hyperinsulinemia work together as “bad actors” to drive atherosclerotic CVD long before a person is diagnosed with type 2 diabetes, and early treatment is needed to slow the process, data show. Read more.

Fatty pancreas increases diabetes risk, but may be reversible with weight loss

Adults with an elevated level of pancreatic fat have higher risk for developing incident diabetes, but weight loss may be able to lower diabetes risk by reducing fat levels and increasing pancreatic volume, according to a presenter at the World Congress on Insulin Resistance, Diabetes and Cardiovascular Disease. Read more.

Bariatric surgery lowers risk for any CV outcome among adults with severe obesity, NAFLD

Adults with nonalcoholic fatty liver disease and severe obesity have a lower risk for CVD if they undergo bariatric surgery vs. those who do not have surgery, according to study findings published in JAMA Network Open. Read more.

Progressive beta cell dysfunction may be primary driver of impaired glucose tolerance

Loss of beta cell function serves as the basis for progression from normal glucose tolerance to impaired glucose tolerance, but insulin clearance may not be a major factor in the development of dysglycemia, according to a speaker at the World Congress on Insulin Resistance, Diabetes and Cardiovascular Disease. Read more.