Top in endocrinology: Type 1 diabetes pill, menopause onset
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TTP399, an investigational oral, once-daily glucokinase activator, received breakthrough therapy designation from the FDA as an adjunctive therapy to insulin for patients with type 1 diabetes. It was the top story in endocrinology last week.
Another top story revealed a potential way to predict when women will begin menopause. Using Cox models with time-dependent covariates associated with age at natural menopause, researchers determined the age for Finnish participants.
Read these and more top stories in endocrinology below:
FDA grants breakthrough therapy designation for novel type 1 diabetes pill
The FDA granted breakthrough therapy designation for TTP399 as an adjunctive therapy to insulin for the treatment of type 1 diabetes, according to a press release from vTv Therapeutics. Read more.
Lifestyle, socioeconomic factors help predict age at natural menopause
Menopause indicators, such as follicle-stimulating hormone and estradiol levels, combined with lifestyle habits and socioeconomic factors may help predict when a woman will begin menopause, according to study data. Read more.
Natural menopause occurring 1.5 years later than in 1959
The mean age for natural menopause and mean reproductive life span both increased for women during a 60-year period from 1959 to 2018, according to a research letter published in JAMA. Read more.
Dapagliflozin fails to prevent organ damage, death in adults hospitalized with COVID-19
Top-line data from the phase 3 DARE-19 trial show that the SGLT2 inhibitor dapagliflozin failed to prevent organ dysfunction and all-cause mortality among hospitalized patients with COVID-19 at risk for developing serious complications. Read more.
Black, Asian, female patients less likely to receive SGLT2 inhibitor prescription
Black, Asian and female patients with type 2 diabetes are less likely to receive a prescription for an SGLT2 inhibitor compared with other groups, even when diagnosed with cardiovascular or kidney disease, a database analysis shows. Read more.