February 11, 2019
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Higher consumption of ultraprocessed food associated with increased mortality

Consuming greater proportions of ultraprocessed foods may increase the risk for all-cause mortality, according to a study published in JAMA Internal Medicine.

Perspective from Gabrielle Mancella, MS

“CVD, respiratory disease, cancer and diabetes account for more than 80% of all premature deaths from noncommunicable disease worldwide,” Laure Schnabel, MD, MSc, of the University of Paris, and colleagues wrote. “Associations between ultraprocessed foods intake and noncommunicable diseases have been documented, but no study has directly investigated the association between ultraprocessed foods consumption and mortality.”

To assess the association between ultraprocessed foods consumption and overall mortality risk, researchers conducted an observational prospective cohort study of adults aged 45 years or greater from the French NutriNet-Sante Study (n = 44,551; 73.1% women; mean age, 56.7 years).

Participants completed at least one set of three web-based 24-hour dietary records during their first 2 years of follow-up. The dietary records consisted of food and beverage consumption at each of the three main daily meals and at any other eating occasion. Using the NOVA food classification, researchers then classified foods into categories according to nature, extent and purpose of processing. Researchers focused on the group classified as ultraprocessed, which was defined as foods that were manufactured industrially from multiple ingredients that usually included additives.

Proportion, calculated by weight, of ultraprocessed foods in the diet was computed for each participant and mortality was assessed using the French national registry of specific mortality causes. Cox proportional hazards regression models were used to estimate the association between ultraprocessed foods proportion and overall mortality.

Participants were followed for a median of 7.1 years. During this time, 602 deaths occurred. Ultraprocessed foods accounted for a mean proportion of 14.4% of the weight of total food consumed.

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Consuming greater proportions of ultraprocessed foods may increase the risk for all-cause mortality.
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Researchers found that, after adjusting for a range of covariates, an increase in ultraprocessed foods consumption was positively associated with all-cause mortality (HR per 10% increment = 1.14; 95% CI, 1.04-1.27) and that ultraprocessed food consumption was associated with younger age, lower income, lower educational level, living alone, higher BMI and lower physical activity level.

“Results suggested a positive association between increased ultraprocessed foods consumption and all-cause mortality risk,” the researchers wrote. “Further studies are needed to confirm those results in different populations and to disentangle the various mechanisms by which ultraprocessed foods may affect health, including both their nutritional features and their food processing-related characteristics. Ultraprocessed foods consumption has largely increased during the past several decades and may drive a growing burden of noncommunicable disease deaths.” – by Melissa J. Webb

Disclosures: The authors report no relevant financial disclosures.