February 11, 2019
4 min read
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Higher consumption of ultraprocessed food associated with increased mortality
Consuming greater proportions of ultraprocessed foods may increase the risk for all-cause mortality, according to a study published in JAMA Internal Medicine.
“CVD, respiratory disease, cancer and diabetes account for more than 80% of all premature deaths from noncommunicable disease worldwide,” Laure Schnabel, MD, MSc, of the University of Paris, and colleagues wrote. “Associations between ultraprocessed foods intake and noncommunicable diseases have been documented, but no study has directly investigated the association between ultraprocessed foods consumption and mortality.”
To assess the association between ultraprocessed foods consumption and overall mortality risk, researchers conducted an observational prospective cohort study of adults aged 45 years or greater from the French NutriNet-Sante Study (n = 44,551; 73.1% women; mean age, 56.7 years).
Participants completed at least one set of three web-based 24-hour dietary records during their first 2 years of follow-up. The dietary records consisted of food and beverage consumption at each of the three main daily meals and at any other eating occasion. Using the NOVA food classification, researchers then classified foods into categories according to nature, extent and purpose of processing. Researchers focused on the group classified as ultraprocessed, which was defined as foods that were manufactured industrially from multiple ingredients that usually included additives.
Proportion, calculated by weight, of ultraprocessed foods in the diet was computed for each participant and mortality was assessed using the French national registry of specific mortality causes. Cox proportional hazards regression models were used to estimate the association between ultraprocessed foods proportion and overall mortality.
Participants were followed for a median of 7.1 years. During this time, 602 deaths occurred. Ultraprocessed foods accounted for a mean proportion of 14.4% of the weight of total food consumed.
Consuming greater proportions of ultraprocessed foods may increase the risk for all-cause mortality.
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Researchers found that, after adjusting for a range of covariates, an increase in ultraprocessed foods consumption was positively associated with all-cause mortality (HR per 10% increment = 1.14; 95% CI, 1.04-1.27) and that ultraprocessed food consumption was associated with younger age, lower income, lower educational level, living alone, higher BMI and lower physical activity level.
“Results suggested a positive association between increased ultraprocessed foods consumption and all-cause mortality risk,” the researchers wrote. “Further studies are needed to confirm those results in different populations and to disentangle the various mechanisms by which ultraprocessed foods may affect health, including both their nutritional features and their food processing-related characteristics. Ultraprocessed foods consumption has largely increased during the past several decades and may drive a growing burden of noncommunicable disease deaths.” – by Melissa J. Webb
Disclosures: The authors report no relevant financial disclosures.
Perspective
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Gabrielle Mancella, MS
These findings can be applied to the United States. The foods consumed were ranked using the NOVA food classification system, which we can also utilize for foods in the United States. The only difference would be what is classified in the United States, as “additives” considered by the U.S. to fit the ultra-processed categorization. This may cause a slight difference in study results. Though, because this information is not new, the overall key points can be translated and, in fact, should likely be reproduced within the United States.
In my experience as a registered dietitian, I do not think these findings are surprising. I do think that consumers need to be able to make the connection to the reasons supporting why this is a significant. For example, this study focuses on “ultra-processed foods.” These are consumed in the form of snacks, desserts, or ready-to-eat or -heat meals. It is important that the take-away point be noted as not just a generalized all-cause mortality risk is increased, but how and precisely what from. The components of these ultra-processed foods per the article are saturated and trans fats, salt, and added sugar from the diet. We are aware that these could present major advantages if we reduce consumption, such as preventing cardiovascular deaths, which here in the United State is a lead cause of mortality in the category of chronic disease. It is important for the consumer to recognize the correlation between which ingredients contribute to the cardiovascular disease (i.e., trans fat, salt, added sugars, etc.) and which of the ultra-processed foods these can be found in. The ultra-processed food concern extends beyond the ingredients and, further speaking, to the food packaging. This is a key take-away point from this study.
In the study, ultra-processed foods accounted for 14.4% of the total weight of food and drink consumed and 29.1% of total energy intake. Food packaging is also suspected to have endocrine disrupting properties. During storage and transportation of food products, chemicals from food-contact articles can migrate into food, some of which might negatively affect health, such as bisphenolA (better recognized as BPA). We experience this when we compare the benefits of organic versus non-organic foods such as canned tomato products in the United States and how the linings of the cans and food components interact with one another. This is an area that needs to be further researched.
Per the article, conversely, ultra-processed foods have generally little fiber content, and higher ultra-processed foods consumption was associated with lower fiber intake, whereas dietary fiber was previously linked with a substantially decreased mortality risk. We know that for the typical American, we are not consuming enough fiber daily. This study points out the correlation between this inverse relationship. This is an area for all consumers to improve on. This study provides an action initiative which, for the consumer, is a wonderful thing. It clearly dictates to reduce the consumption of ultra-processed foods not only to decrease our risk for all-cause mortality (whether it be cardiovascular disease or other) but also to begin to substitute these foods for higher quality alternatives. When doing so, we can increase fiber, nutrient intake, and an array of other essential nutrients required from food that we previously were not receiving. A recommendation I counsel to any of my patients is that if you do not know where to start, try to eat nothing out of a box.
Gabrielle Mancella, MS
Registered Dietician
Orlando Health
Disclosures: Mancella reports no relevant financial disclosures.