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Top stories in gastroenterology: bile acid sequestrant improves effect of proton pump inhibitor, fecal transplant alters gut microbiome in IBS patients
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The top stories in gastroenterology focus on data presented at Digestive Disease Week. One trial showed that a bile acid sequestrant improved heartburn and regurgitation when paired with a proton pump inhibitor. A study showed that fecal microbiota transplantation altered the gut microbiota of patients with irritable bowel syndrome but was not superior to placebo for improving symptoms. Other top stories include a study that found that patients with ulcerative colitis had higher remission rates when treated with Entyvio, a report that clinical outcomes in treatment of Clostridium difficile infection are not impacted by fecal transplant donor profile, and the finding that more than one-third of patients hospitalized for constipation are readmitted within 90 days.
Bile acid sequestrant improves effects of PPI in persistent GERD
A bile acid sequestrant improved heartburn and regurgitation when paired with a proton pump inhibitor in patients with persistent GERD, according to the results of a phase 2b trial. Read More.
Fecal transplant alters gut microbiome in IBS patients
Fecal microbiota transplantation altered the gut microbiota of patients with irritable bowel syndrome, but it was not superior to placebo for improving symptoms in a study. Read More.
More UC patients achieve remission with Entyvio vs. anti-TNF
Patients with ulcerative colitis treated with Entyvio had higher remission rates compared with patients treated with TNF antagonists, researchers reported. Read More.
Fecal transplant outcomes not impacted by donor profile
Fecal transplant donor profile does not appear to impact clinical outcomes in the treatment of Clostridium difficile infection, researchers reported. Read More.
Rehospitalization common among patients admitted for constipation
More than one-third of patients hospitalized for constipation are readmitted within 90 days, and clinical rather than demographic factors were key predictors of readmission, researchers reported. Read More.