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Top stories in endocrinology: glyburide acceptable therapy in gestational diabetes, early menarche increases diabetes risk

Among the stop stories in endocrinology is the finding that French women with gestational diabetes receiving oral glyburide therapy during pregnancy were more likely to deliver infants with complications versus women using insulin therapy. Data analyzed shows that a proinflammatory diet is not associated with increased risk for all-cause and cardiovascular mortality among adults with metabolically healthy obesity. Other stories include higher coffee consumption being associated with greater risk for hip fracture in postmenopausal Chinese women, transgender women on a long-term regimen of estrogen and spironolactone therapy are not experiencing a clinically relevant change in prolactin level, and girls entering menarche at age 10 years or younger are 18% more likely to develop type 2 diabetes.

In gestational diabetes, glyburide may be acceptable therapy option

French women with gestational diabetes who received oral glyburide therapy during pregnancy were more likely to deliver infants with complications such as macrosomia and neonatal hypoglycemia vs. women assigned to insulin therapy, according to findings published in JAMA. Read More.

In metabolically healthy obesity, no link between proinflammatory diet, all-cause mortality

Among adults with metabolically healthy obesity, a proinflammatory diet is not associated with increased risk for all-cause and cardiovascular mortality, but this risk persists for those with metabolically unhealthy obesity who adhere to the same diet, according to findings published in Clinical Nutrition. Read More.

Coffee drinking linked to hip fracture risk in postmenopausal Chinese women

Drinking at least four cups of coffee per day may confer a greater risk for hip fracture in postmenopausal Chinese women, whereas moderate coffee consumption appears to reduce risk, according to results published in Bone. Read More.

Estrogen plus spironolactone therapy not associated with prolactin levels in transgender women

Transgender women on a long-term regimen of estrogen and spironolactone therapy did not experience a clinically relevant change in prolactin level, suggesting the therapy combination is safe in this population, according to findings from a retrospective study published in Endocrine Practice. Read More.

Reproductive factors influence diabetes risk in women

Girls who enter menarche at age 10 years or younger are 18% more likely to develop type 2 diabetes vs. girls who enter menarche at age 13 years or older, whereas women who have never given birth are at greater risk for the disease vs. women who have had at least two children, according to an analysis of pooled data published in Diabetes, Obesity and Metabolism. Read More.