Top stories in gastroenterology: new endoscopic eradication therapy guidelines, recommendations on GI bleeding

Among the top stories in gastroenterology is new guidelines released by the American Society for Gastrointestinal Endoscopy on the use of endoscopic eradication therapy among individuals with Barrett’s esophagus-related dysplasia and intramucosal cancer. Synthetic Biologics withdrew a breakthrough therapy designation for ribaxamase, its Clostridium difficile drug. Other stories include new updates, tips and tricks for endoscopists to manage non-variceal upper gastrointestinal bleeding, a phase 2 trial showed positive results for patients with rectal cancer, and alcohol consumption correlated with changes to the oral microbiome that were linked to alcohol-related diseases.

ASGE issues guidance on endoscopic eradication in Barrett’s esophagus

The American Society for Gastrointestinal Endoscopy has released new guidelines on the use of endoscopic eradication therapy in patients with Barrett’s esophagus-related dysplasia and intramucosal cancer. Read More.

FDA breakthrough status withdrawn for C. difficile drug candidate

Synthetic Biologics announced it has withdrawn the breakthrough therapy designation for its Clostridium difficile drug candidate SYN-004 (ribaxamase) after an FDA review of safety data from a phase 2b clinical trial. Read More.

Updates, Tips and Tricks in the Ever-Changing Landscape of Upper GI Bleeds

As technology improves and patients enter care with more advanced bleeds and more co-morbidities than ever before, endoscopists must stay on top of the latest tips, tricks, technology and techniques to manage non-variceal upper gastrointestinal bleeding (UGIB). Read More.

Endoscopic approach to rectal cancer surgery shows promise

Transanal endoscopic total mesorectal excision showed positive results in a phase 2 trial of patients with rectal cancer, according to research published in Diseases of the Colon & Rectum. Read More.

Alcohol linked to potentially harmful changes in oral microbiome

Alcohol consumption correlated with significant changes to the oral microbiome that have been previously linked to alcohol-related diseases like periodontal disease, GI cancers, head and neck cancers and heart disease, according to new research published in the journal Microbiome. Read More.