Top stories in hematology and oncology: improved breast cancer outcomes, bright white light therapy beneficial among cancer survivors

Among the top stories in hematology and oncology is an in-depth look at how the discovery and development of effective targeted therapies have improved the outcomes of breast cancer over the past decade. Bright white light therapy has produced beneficial effects among cancer survivors who used the treatment in the morning. Other stories include a study in which researchers identified genomic alterations that defined four subtypes of diffuse large B-cell lymphoma, the phase 3 KEYNOTE-042 trial of pembrolizumab met its primary endpoint of OS, and adhering to the American Cancer Society’s exercise, weight and nutrition guidelines showed a reduce risk of death among patients with colon cancer.

Deeper understanding of disease biology may improve outcomes in triple-negative breast cancer

The discovery of predictive biomarkers and the subsequent development of effective targeted therapies have dramatically improved breast cancer outcomes over the past decade. Read More.

Bright white light therapy reduces fatigue among cancer survivors

Cancer survivors who used systematic bright white light therapy in the mornings experienced reduced disturbances in sleep, decreasing fatigue, according to results of a randomized trial. Read More.

Researchers identify distinct genetic subtypes of diffuse large B-cell lymphoma

Researchers identified genomic alterations that defined four subtypes of diffuse large B-cell lymphoma that may predict which patients will respond to treatment and have longer OS, according to study findings published in The New England Journal of Medicine. Read More.

First-line Keytruda improves survival for non-small cell lung cancer

The phase 3 KEYNOTE-042 trial of pembrolizumab met its primary endpoint of OS for the first-line treatment of patients with locally advanced or metastatic non-small cell lung cancer with PD-L1 expression, according to the agent’s manufacturer. Read More.

Adherence to nutrition, physical activity guidelines reduces colon cancer mortality risk

Following American Cancer Society’s exercise, weight and nutrition guidelines appeared associated with a reduced risk for death among patients with colon cancer, study data showed. Read More.