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VIDEO: Refined definition of sepsis should help avoid underdiagnosis
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WASHINGTON — Research into the diagnosis and management of sepsis that was published in 2015 should improve patient care, Nathan E. Brummel, MD, MSCI, said at the American College of Physicians Internal Medicine Meeting.
Brummel, from Vanderbilt University School of Medicine, stated that under the updated definition, sepsis is now considered a systemic host dysregulatory response to infection, replacing the old systemic inflammatory response syndrome (SIRS)-based definition.
“These definitions are appealing for several reasons – one is that they are anchored in outcomes, so we know that this definition of sepsis is associated with worse outcomes for patients,” Brummel said.
Brummel also discussed the ProMISe trial, which showed no benefit from early, goal-directed therapy for sepsis.