Latest research on proton pump inhibitors for physicians

Healio.com/Internal Medicine presents the latest research on the use of proton pump inhibitors, including possible implications of usage and prescription guidelines for physicians.

Much of the research from the past year covered by Healio focused on how PPI use increases the risk for various adverse events, such as myocardial infarction, fractures and chronic kidney disease.

PPI use linked to increased risk for chronic kidney disease

Using PPIs was associated with a higher risk for incident chronic kidney disease, according to study results published in JAMA Internal Medicine. Read more.

PPIs increase risk for in-hospital mortality from infections

A recent study found that use of PPIs to reduce heartburn or prevent GI bleeding in hospital inpatients increases their risk for dying of infections. Read more.

PPIs may increase fracture risk in older women

Older women who use PPIs to reduce stomach acid may increase their risk for fracture, according to research in Bone. Read more.

PPIs may increase MI risk

Adults in the United States exposed to PPIs were at increased risk for MI in a recent data-mining study. Read more.

PPIs linked to higher mortality in patients with cirrhosis

Patients with cirrhosis had a greater risk for death while using PPI treatment, according to new study results. Read more.

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Judicious PPI use necessary to avoid serious adverse events

A recent review article detailed the potential harms associated with use of PPIs, concluding that physicians should follow Health Canada’s recommendations that the drugs “should be prescribed at the lowest dose and shortest duration of therapy appropriate to the condition being treated.” Read more.

PPIs impact specific gut microbiota associated with C. difficile infection

Researchers observed significant changes in gut microbiota that are associated with Clostridium difficile infection and gastrointestinal bacterial overgrowth in participants using PPIs in a small crossover study. Read more.

PPI use not associated with risk for spontaneous bacterial peritonitis

Researchers in Argentina did not find an association between PPI use and high risk for spontaneous bacterial peritonitis among patients with cirrhosis, according to published data. Read more.

PPIs increase risk for NSAID-induced small bowel injury

PPIs were found to increase the risk for small bowel injury in patients taking NSAIDs in a Japanese trial. Read more.

PPIs induce remission in half of patients with symptomatic esophageal eosinophilia

PPIs induce clinical and histologic remission in approximately half of patients with symptomatic esophageal eosinophilia, according to results from a systematic review and meta-analysis. Read more.