Use of gabapentinoids may be associated with increased risk of hip fracture
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Key takeaways:
- Use of gabapentinoids may be associated with an increased risk of hip fracture in older patients.
- Patients who were frail and patients with chronic kidney disease were at increased risk for hip fractures.
According to published results, the use of gabapentinoids may be associated with an increased risk of hip fractures in older, frail patients and patients with chronic kidney disease.
Miriam T. Y. Leung, MClinPharm, from the Centre for Medicine Use and Safety at Monash University in Australia, and colleagues performed a study of 28,293 patients who were hospitalized for hip fractures in Australia between March 2013 and June 2018. Leung and colleagues noted most patients were aged 80 years or older (59.5%) and were women (71.2%).
Among the cohort, 2,946 patients filled at least one prescription for a gabapentinoid before their injury. Leung and colleagues noted pregabalin was the most commonly used gabapentinoid. Of these patients, 2,644 were matched by age and sex with 12,920 future-case control patients.
Overall, Leung and colleagues found the use of gabapentinoids was associated with significantly increased odds of hip fracture compared with the control group (OR = 1.96). In addition, they found the use of gabapentinoids was associated with increased risk of hip fractures among patients with a Hospital Frailty Risk Score of five and more (OR = 1.75) and patients with chronic kidney disease (OR = 2.41).
“These findings suggest that in addition to the known risk associated with kidney impairment, gabapentinoids should be used with caution among patients at risk of hip fractures, especially those who are frail,” Leung and colleagues wrote in the study.
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