VIDEO: Xywav safe, efficacious, preferred over Xyrem in adults with narcolepsy

INDIANAPOLIS — For adults with narcolepsy, a switch in treatment to Xywav was safe, efficacious and preferred over treatment with Xyrem on a gram-for-gram basis, according to Wayne Macfadden, MD, in a Healio video from SLEEP 2023.

Macfadden and colleagues sought to assess the safety, efficacy, tolerability, sleep quality and preferences of those who switched from Xyrem (sodium oxybate, Jazz Pharmaceuticals) to Xywav (calcium, magnesium, potassium and sodium oxybates; Jazz Pharmaceuticals) in the SEGUE trial, a multicenter, open-label interventional switch study of approximately 60 adults with narcolepsy.

Researchers found that a majority of participants made the switch with minimal dose or regimen adjustments while reporting ease in the transition process.

“Safety and tolerability were similar; people seem to actually prefer Xywav to Xyrem,” Macfadden, sleep therapeutic area lead for the global medical affairs division at Jazz Pharmaceuticals, said. “Quality of sleep was also maintained after the switch.”

In addition, Macfadden stated effectiveness of Xywav was maintained following the switch from Xyrem.