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Neurorehabilitation News
Dalzanemdor fails to meet endpoints in phase 2 study of patients with Huntington’s disease
A phase 2 clinical trial of dalzanemdor in those with cognitive impairment associated with Huntington’s disease failed to meet its primary and secondary endpoints, causing the manufacturer to halt development of the investigational therapy.
Daily dose of oral edaravone for ALS nonsuperior to staggered regimen at 48 weeks
For individuals with ALS, a daily dosing regimen of oral edaravone was nonsuperior to an FDA-approved staggered regimen of the drug plus placebo, according to a poster presented at AANEM.
FDA approves novel gene therapy for rare neurometabolic disorder
The FDA has approved an adeno-associated virus vector-based gene therapy to treat both adult and pediatric patients with aromatic L-amino acid decarboxylase deficiency.
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IV nipocalimab reduces disease expression in generalized myasthenia gravis
Treatment with IV nipocalimab was safe and led to significant reductions in disease expression at 24 weeks in adolescents with generalized myasthenia gravis, according to data presented at AANEM.
Koselugo significantly reduces neurofibromas in ongoing phase 3 study
An oral therapeutic significantly reduced the number of tumors in adults with neurofibromatosis type 1 who have symptomatic, inoperable plexiform neurofibromas, according to topline results from a phase 3 study.
Predelivery concussion linked to increased risk for severe maternal mental illness
Individuals with a predelivery history of concussion appeared to be at increased risk for severe maternal mental illness, highlighting the importance of screening and supportive care for this high-risk group, according to researchers.
Retention of memories can lie in cells outside of the brain
Features of memory retention in cells may result from embedded signaling dynamics in the body, with information stored best in spaced bursts rather than in a single, massed event, according to research from Nature Communications.
Uplizna treatment shows greater improvement in myasthenia gravis compared with placebo
IV administration of Uplizna was safe and shown to be more efficacious for those with generalized myasthenia gravis compared with placebo at week 26, according to a presentation from AANEM.
White matter alterations in brain strongly associated with cognitive impairment
Alterations in white matter integrity were linked to cognitive impairment, and associations were strongest in those with major depressive disorder compared with healthy controls, according to new research.
IV administration of fasudil safe, well tolerated in ALS
IV administration of fasudil at two separate doses was safe and well tolerated in a small cohort of individuals with suspected or confirmed ALS, according to new research published in The Lancet.
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Headline News
Q&A: ‘We have to be worried’ about decline in measles vaccination
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Physicians encouraged to ‘embrace’ technology in practice management
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Artificial neural network has ‘excellent’ performance in predicting COPD exacerbations
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Headline News
Q&A: ‘We have to be worried’ about decline in measles vaccination
November 19, 20244 min read -
Headline News
Physicians encouraged to ‘embrace’ technology in practice management
November 19, 20245 min read -
Headline News
Artificial neural network has ‘excellent’ performance in predicting COPD exacerbations
November 20, 20242 min read