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Neuro-Oncology News
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FDA approves Gomekli for neurofibromatosis type 1 with plexiform neurofibromas
The FDA has approved an oral, small molecule MEK inhibitor for adult and pediatric patients 2 years of age and older with neurofibromatosis type 1 who have symptomatic plexiform neurofibromas not amenable to complete resection.
Exposure to CT radiation increases risk for childhood brain tumors
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Exposure to radiation from head or neck CT imaging increased risk for childhood brain tumors, according to results of a nationwide population-based study conducted in Finland.
Temozolomide regimen extends survival for people with grade 2 gliomas
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The addition of temozolomide to radiation therapy prolonged OS for patients with both co-deleted and non-co-deleted grade 2 gliomas, according to study results.
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Malignant glioma diagnosed earlier in men
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An analysis of adults with malignant glioma revealed that men were diagnosed at a younger age and women had worse preoperative status, but researchers found no other sex-related differences or clinical advantage.
CAR T-cell therapy produces ‘jaw dropping’ results for deadly pediatric brain tumors
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Chimeric antigen receptor T-cell therapy can reduce tumor burden and improve neurologic function for patients with certain brain and spinal cord cancers, a first-in-human clinical trial showed.
De-escalated adjuvant chemotherapy effective for high-risk retinoblastoma
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A shortened adjuvant chemotherapy regimen improved outcomes for infants with unilateral pathologic high-risk retinoblastoma, according to study results.
Addition of veliparib to temozolomide fails to extend survival in glioblastoma
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The addition of veliparib to adjuvant temozolomide failed to improve OS for patients with newly diagnosed, MGMT-hypermethylated glioblastoma, according to randomized phase 2/phase3 study results.
MS linked to greater risk for certain cancers
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People with MS had an increased risk for bladder, brain and cervical cancers compared with people without MS, according to a new study in Neurology, the medical journal of the American Academy of Neurology.
Trial to assess personalized vaccine for aggressive brain tumors
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A first-in-human clinical trial will assess the safety of a personalized vaccine to treat diffuse hemispheric glioma, an aggressive brain tumor.
Young children treated for brain tumors less ready for school than their peers
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Young children who underwent treatment for brain tumors had lower academic readiness scores than their peers, according to results of a prospective longitudinal trial.
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