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Steatohepatitis/Metabolic Liver Disease News

Larsucosterol flops on clinical benefit in phase 2b alcohol-associated hepatitis trial
The AHFIRM trial did not demonstrate a beneficial effect of larsucosterol on 90-day mortality or the need for liver transplant among patients with severe alcohol-associated hepatitis, or AH, according to a study published in NEJM Evidence.
Metabolic surgery slashed risk for adverse outcomes in MASH-related cirrhosis, obesity

Metabolic surgery significantly lowered risk for major adverse liver outcomes vs. nonsurgical management among patients with obesity and compensated cirrhosis from metabolic dysfunction-associated steatohepatitis, according to study data.
Q&A: Surgeon General’s warning exposes public ‘knowledge gap’ of alcohol links to cancer

There are approximately 100,000 alcohol-related cancer cases annually in the U.S. and 20,000 deaths due to alcohol-related cancer, according to an HHS press release.
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US cases of MASLD projected to top 121 million by 2050 alongside 55% spike in MASH

A new model has projected a substantial rise in the burden of metabolic dysfunction-associated steatotic liver disease in the U.S. by 2050, which could be minimized by effective preventive and management strategies, researchers wrote.
Q&A: Dry January trend ‘could be a wake-up call’ on risk for alcohol-related liver disease

Dry January has become an increasingly popular trend in which people abstain from alcohol use for 1 month to reset their health after the holiday season. But, for some, it could be a wake-up call about their struggles with alcohol.
Q&A: Prenatal chemical exposure linked to liver injury in mothers, children 10 years later

Exposure to environmental chemicals during pregnancy may increase the risk for liver injury and steatosis in children and mothers, which could be mitigated by higher folic acid supplementation, according to a study in Journal of Hepatology.
‘Alarming’ rise in alcohol-associated hepatitis reported in female teenagers, young adults

From 2002 to 2021, the incidence rate of alcohol-associated hepatitis “more than doubled” among adolescents and young adults in Ontario, Canada, with the highest uptick observed among females, according to research in JAMA Network Open.
Link between fatty liver disease, hot flash severity ‘hard to tease apart’

Midlife women with a metabolic dysfunction-associated steatotic liver disease diagnosis were more likely to report severe or very severe hot flashes, though researchers found no direct link between the two conditions, data show.
Endoscopic sleeve gastroplasty ‘effective alternative’ for MASH, obesity management

Endoscopic sleeve gastroplasty with lifestyle intervention was more effective than lifestyle changes alone in achieving weight loss and histological improvement in patients with metabolic dysfunction-associated steatohepatitis and obesity.
Hispanic patients with alcohol use disorder face greater odds for hepatitis, cirrhosis

Hispanic patients hospitalized for alcohol use disorder were more likely to develop alcohol-associated hepatitis, decompensated cirrhosis and related complications compared with non-Hispanic white patients, according to published data.
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Headline News
Societies take stand against off-brand GLP-1s over safety concerns
March 17, 202515 min read -
Headline News
THA stem design may have a larger impact on periprosthetic fracture risk vs. cement use
February 06, 20251 min read -
Headline News
Self-perceived stress linked to cryptogenic ischemic stroke in young women
March 14, 20253 min read