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November 22, 2024
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‘Truly alarming’: Life expectancy gap in the US now up to 20 years

Autoimmune/Cholestatic/Biliary Diseases News

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December 13, 2023
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VIDEO: Preclinical research investigates role of Claudin-1 in cholangiocarcinoma

VIDEO: Preclinical research investigates role of Claudin-1 in cholangiocarcinoma

BOSTON — Healio spoke with James L. Boyer, MD, FACEP, about research assessing the role of Claudin-1 in cholangiocarcinoma, which was presented at The Liver Meeting.

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December 07, 2023
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Patients with MASLD lost less weight after bariatric surgery, study finds

Patients with MASLD lost less weight after bariatric surgery, study finds

BOSTON — Patients with metabolic dysfunction-associated steatotic liver disease who underwent bariatric surgery lost less weight over 5 years than those without MASLD, according to research presented at The Liver Meeting.

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November 22, 2024
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‘Truly alarming’: Life expectancy gap in the US now up to 20 years

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November 29, 2023
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Elafibranor achieves response, improves pruritus symptoms in primary biliary cholangitis

Elafibranor achieves response, improves pruritus symptoms in primary biliary cholangitis

BOSTON — After 52 weeks, elafibranor achieved biochemical response and improved symptoms of pruritus in patients with primary biliary cholangitis, according to late-breaking data presented at The Liver Meeting.

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November 22, 2023
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VIDEO: Primary biliary cholangitis treatments poised to be clinically ‘impactful’

VIDEO: Primary biliary cholangitis treatments poised to be clinically ‘impactful’

BOSTON — Healio spoke with James L. Boyer, MD, about phase 3 findings from the RESPONSE trial and the ELATIVE trial and presented at The Liver Meeting.

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November 16, 2023
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FDA grants fast track status to monoclonal antibody for primary sclerosing cholangitis

FDA grants fast track status to monoclonal antibody for primary sclerosing cholangitis

The FDA has granted fast track designation to Chemomab Therapeutics’ anti-CCL24 monoclonal antibody, CM-101, for the treatment of adults with primary sclerosing cholangitis, according to a manufacturer release.

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November 16, 2023
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VIDEO: Treatment with Livmarli yields ‘broad base effects’ across range of PFIC types

VIDEO: Treatment with Livmarli yields ‘broad base effects’ across range of PFIC types

BOSTON — In a Healio video exclusive, Pam Vig, PhD, reports late-breaking data that show Livmarli improved liver health and maintained symptom response over 2 years among pediatric patients with progressive familial cholestasis.

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October 11, 2023
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Robotic-assisted cholecystectomy linked to higher rates of bile duct injury, complications

Robotic-assisted cholecystectomy linked to higher rates of bile duct injury, complications

Although the use of robotic-assisted cholecystectomy increased 37-fold from 2010 to 2019, the procedure was associated with significantly higher rates of bile duct injury compared with laparoscopic cholecystectomy, according to research.

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September 09, 2023
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‘Ask me about PBC’ campaign calls on patients to speak up for rare liver disease

 ‘Ask me about PBC’ campaign calls on patients to speak up for rare liver disease

International Primary Biliary Cholangitis Day, celebrated on September 10, aspires to raise awareness of the challenges that patients with this rare liver disease face and how their stories can help advance diagnosis, treatment and care.

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September 08, 2023
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FDA grants orphan drug designation to inhaled therapy for alpha-1 antitrypsin deficiency

FDA grants orphan drug designation to inhaled therapy for alpha-1 antitrypsin deficiency

The FDA granted orphan drug designation for KB408 for the treatment of alpha-1 antitrypsin deficiency, according to a press release from Krystal Biotech.

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September 07, 2023
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RESPONSE topline data: Seladelpar normalized alkaline phosphatase, reduced pruritus in PBC

RESPONSE topline data: Seladelpar normalized alkaline phosphatase, reduced pruritus in PBC

Seladelpar reduced serum alkaline phosphatase and bilirubin at 12 months in more than 60% of patients with primary biliary cholangitis compared with 20% of placebo-treated patients, according to manufacturer, CymaBay Therapeutics.

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