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Systematic vascular resistance inversely correlated with multiple liver scoring systems

Patients with decompensated cirrhosis who were hyponatremic experienced an inverse correlation between systematic vascular resistance and their scores from multiple liver disease severity models, according to study data.  

Vinaya V. Gaduputi, MD, department of gastroenterology, Bronx Lebanon Hospital Center, and colleagues analyzed electronic medical records of 771 patients with decompensated cirrhosis admitted to the Bronx Lebanon Hospital, New York, between 2002 and 2012. Serum sodium, serum bilirubin and other laboratory data were collected and analyzed. MELD and iMELD scores were also calculated.

Vinaya V. Gaduputi

Of all the patients, 262 were hyponatremic and 509 were normonatremic and had normal sodium levels >135 mEq/L. Hyponatremic patients had higher MELD scores (P=.0001) compared with normonatremic patients. Through multiple analyses, researchers determined an inverse correlation between systemic vascular resistance (SVR) and MELD sodium score (P=.0322) and with MELD sodium score (P=.0194) in patients with hyponatremia compared with normonatremic patients. Inverse correlations were also found in SVR and integrated MELD scores (P=.0266), SVR and MELD to serum sodium ration (MESO) scores (P=.0356) and SVR and U.K. MELD (UKELD) scores (P=.0225) in patients with hyponatremia compared with patients with normonatremia.   

“We found significant correlation between systemic vascular resistance and multiple validated liver disease severity scoring systems in our retrospective study,” Gaduputi told Healio.com/Hepatology. “This correlation was significant only in patients with hyponatremia. We hypothesize that measurement of systemic vascular resistance could be a valuable stand-alone tool in dynamic monitoring of liver disease severity, however, a well-designed large scale prospective study is needed to validate it.”

Disclosure: The researchers report no relevant financial disclosures.