VIDEO: Advances improve accuracy of mantle cell lymphoma diagnosis

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To be honest, very good progress has been made in recent years that have really allowed us to make this diagnosis relatively consistently. And I would say, that for a number of reasons, one is, the clinical context in which patients present, I think, again, is appreciated. And what I mean by that is, there are some who present with the very typical lymphadenopathy kind of process and a biopsy, then under the microscope, you know, shows a CD5 positive, but notably, cyclin D1 positive disease, which really allows the pathologist to make the diagnosis.

There's a second context of a more indolent process, and in that case, more in the way of a leukemic phase, often with the bigger spleen, those may be a little more difficult to anticipate that they are mantle cell lymphoma, but quite frankly, most pathologists would be very attuned to that and the flow cytometry picture, and then the subsequent confirmation of either the translocation or overexpression of cyclin D1 and often, SOX11 is also analyzed, that would help to make a definitive diagnosis, There are some mantle cell lymphomas that are a little more tricky, possibly because they don't express cyclin D1, those are unusual.

So I would say, in general, the more typical mantle cell lymphoma is relatively reliably diagnosed by a hematopathologist. And again, if there are any questions, I think from a treating clinician's perspective, a discussion with your hematopathologist explaining your findings clinically, will often help them to make sure that they think about mantle cell lymphoma, if for any reason they have not been doing that.