Part 3: The History of IV Immunoglobulin
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Learn about the discovery of immunodeficiencies leading to the use of pooled immunoglobulin as therapy, the struggle to use it intravenously and the eventual use in autoimmune disease.
- Intro :11
- In this episode :15
- Splitting Part 3 into two episodes :26
- Part A of the history of IV Ig and the antibody :53
- A recap on Cohn fractionation 2:40
- The history and uses of IV Ig 4:30
- What led to the recognition and research of primary immunodeficiencies 7:08
- How Charles Janeway Sr. paved the way for IV Ig from intramuscular Ig 9:01
- What are protein aggregates? 12:54
- Understanding the various mechanisms of Ig reactions 15:49
- Managing patients with low IgA and anti-IgA antibodies 18:36
- How to go from treating immunodeficiency to treating autoimmunity 21:40
- The modern understanding and mystery of IV Ig 25:30
- Quick summary 26:05
- Thanks for listening! 27:30
We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum
References:
Barandun S, et al. Vox Sang. 1962;7:157-174.
Eibl MM. Immunol Allergy Clin North Am. 2008;28:737-764, viii.
Furusho K, et al. Lancet. 1983;2:1359.
Gallagher PE, Buckley RH. J Allergy Clin Immunol. 1982;69:120.
Guo Y, et al. Front Immunol. 2018;9:1299.
Imbach P, et al. Lancet. 1981;1:1228-31.
Kustiawan I. PLoS ONE. 2018;13: e0195729. https://doi.org/10.1371/journal.pone.0195729.
MRC Working Party on Hypogammaglobulinaemia. Hypogammaglobulinaemia in the United Kingdom. London: Her Majesty’s Stationery Office; 1971.
Oransky I. Lancet. 2003;362:409.
Sandler SG, et al. Transfus Med Rev. 1995;9:1-8.
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