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December 07, 2023
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VIDEO: TNF inhibitors safe for RA-ILD, but ‘unlikely they have much efficacy’

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SAN DIEGO — In this video, Jeffrey A. Sparks, MD, MMSc, spoke with Healio about the safety of TNF inhibitors compared with alternative targeted therapies for patients with rheumatoid arthritis-associated interstitial lung disease.

The findings were presented at ACR Convergence 2023.

“This kind of affirms that maybe it is safe to use TNF inhibitors in [rheumatoid arthritis-associated interstitial lung disease] RA-ILD patients which I think is a bit practice-changing [because] it is something that is typically avoided in RA-ILD patients,” said Sparks, an associate professor of medicine at Harvard Medical School and an associate program director of the Rheumatology Fellowship, director of Immuno-Oncology and Autoimmunity and director of the Joint Biology Consortium Human Biosamples Core at Brigham and Women’s Hospital. “However, I would say that TNF inhibitors, while they might be safe from a respiratory perspective, it’s probably unlikely they have much efficacy. So, I think the jury’s still out as far as what is the best medication to use when someone has active RA and active lung disease.”