Tardive Dyskinesia Clinical Case Review

Christoph U. Correll, MD, professor of psychiatry at The Zucker School of Medicine at Hofstra/Northwell and professor and chair of the department of child and adolescent psychiatry at Charité University Medicine in Berlin, Germany, discusses the results of the second case.

Editor’s note: The following is an automatically generated transcript of the above video.

"So the treatment with deutetrabenazine resulted in significant improvements in Ida's tardive dyskinesia symptoms, which by week six, reduced facial movements sufficiently to not interfere with customer facing tasks at work, and by eight week, actually reduce the finger movement sufficiently, not to interfere with typing when she was doing her secretarial work. So let's look at that in more detail. At baseline, she had basically three 2s, facial expression, lips, tongue, and one 3, which is moderate in the fingers, bringing her to a nine, and she was started on the 12 milligram starting dose.

Here, the titration, which could have been weekly, was done every two weeks. She's sensitive, always increasing by six milligrams. So by week two, she had 18 milligrams, and she had already one reduction on facial expression and one point reduction on the tongue movement, bringing her to a seven. Then two weeks later, she was put again on 24 milligrams, but she's on 18 for two weeks. Here you can see that she brought down a little bit the finger movements. The rest stayed the same. Then after another two weeks, increased to 30 milligrams, the facial expression has gone, the movement, and she has only minimal, barely noticeable lip and tongue movements. Still has the mild symptom on the fingers up until week eight, but has no change. She has still four.

But then by week 12, after week eight, she really reduced the further movements by another two points, having only borderline minimal movement in the tongue and fingers. No mild movements anymore, and that's sustained out to month six. And so with just two minimal movements, barely noticeable at work and not interfering with her functioning, she's much happier."