Tardive Dyskinesia Clinical Case Review

Christoph U. Correll, MD, professor of psychiatry at The Zucker School of Medicine at Hofstra/Northwell and professor and chair of the department of child and adolescent psychiatry at Charité University Medicine in Berlin, Germany, discusses the results of the first case.

Editor’s note: The following is an automatically generated transcript of the above video.

"What happened then to the movements? The treatment with valbenazine resulted in significant improvements in Paul's TD, which stopped also the negative comments by others, which led to a reduction of secondary social withdrawal and feeling distressed and upset. At baseline, just to remind ourselves, he had two twos and two threes. On that day when the assessment was done for baseline, 40 milligrams was started of valbenazine. Four weeks later, he's increased to 80. He had some improvement.

He went from a 10 to an eight with a slight decrease in the jaw movement and also in the lip movements, which was the puckering. Four weeks later, again, we are keeping him at the best working dose that he tolerates well. There's a further decrease by two points. Now, the facial expression, which was the eye blinking, also goes from mild to minimal. He keeps his puckering at a two. He also keeps the jaw movement level at a minimal, and the tongue movement that was moderate goes to mild. Another four weeks later, actually the eye blinking is gone and the jaw movements are gone.

He has a minimal movement on lips and a mild movement in the tongue. And then at week 24, he has some mild and intermittent movement only on the tongue. So with that, he would also not diagnostically qualify anymore for tardive dyskinesia, which, course, as I said, you need two areas of the body to have a two or one area with a rating of a three."