Hyaluronic acid, bone marrow aspirate concentrate provide long-term cartilage augmentation
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Key takeaways:
- Cartilage repair with a hyaluronic acid-based scaffold and bone marrow aspirate concentrate may yield positive long-term outcomes.
- The study was performed in patients with full-thickness chondral lesions.
Published results showed positive long-term clinical and functional outcomes for patients with knee chondral defects who underwent one-step cartilage repair with a hyaluronic acid-based scaffold and bone marrow aspirate concentrate graft.
Graeme P. Whyte, MD, MSc, clinical assistant professor in the department of orthopedic surgery at NYU Grossman School of Medicine and NYU Langone Health, and colleagues performed a prospective case study of 26 patients (mean age, 48.3 years) who underwent one-step cartilage repair for full-thickness chondral lesions (mean size, 6.6 cm2) with a mean follow-up of 14 years.
According to the study, all patients were treated with a hyaluronic acid-based polymer (Hyalofast, Anika Therapeutics) and bone marrow aspirate concentrate graft (BMAC Harvest Smart PreP2 System, Harvest Technologies).
Overall, 22 patients were included in the final analysis. Three patients failed treatment, and one patient required unicompartmental arthroplasty 12 years after initial hyaluronic acid and bone marrow aspirate concentrate treatment.
Whyte and colleagues found median preoperative VAS pain scores decreased from 5 to 0.6 postoperatively. They also found median KOOS score for all subscales improved from preoperatively to postoperatively. At final follow-up, the median KOOS pain score was 92, median KOOS symptoms score was 86, median KOOS activities of daily living score was 96, median KOOS sports score was 85 and median KOOS quality of life sore was 88.
Whyte and colleagues concluded this one-step, cell-based treatment may not only yield long-term clinical and functional success, but also provide a routine, cost-effective option for patients with full-thickness chondral lesions.
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