Osteochondral allograft had similar results as cell-based therapy for cartilage lesions
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Key takeaways:
- Osteochondral allograft vs. cell-based therapy yielded similar outcomes for patients with patellofemoral cartilage defects.
- All interventions had similar functional outcomes, return to sport and satisfaction.
Published results showed osteochondral allograft transplantation, autologous chondrocyte implantation and matrix-induced autologous chondrocyte implantation all yielded similar outcomes for patients with patellofemoral cartilage defects.
Researchers performed a retrospective review of 95 patients with patellofemoral articular cartilage defects who underwent osteochondral allograft (OCA) transplantation (n = 40) vs. autologous chondrocyte implantation (ACI) or matrix-induced autologous chondrocyte implantation (MACI) (n = 55). Outcome measures were assessed at a mean follow-up of 63.8 months and included KOOS scores, VAS pain scores and return to sport.
Researchers noted tibial tubercle osteotomy was performed concomitantly with 66% of OCA procedures and with 98% of ACI or MACI procedures.
Overall, researchers found patients who underwent OCA had KOOS pain scores of 74.7 compared with 83.6 for patients who underwent ACI or MACI at final follow-up. They noted this difference was significant. However, researchers found no other significant differences between the groups for any other functional outcomes, return to sport or patient satisfaction at final follow-up.
In addition, researchers noted older patient age was associated with decreased satisfaction among patients who underwent OCA and worse outcomes for patients who underwent ACI or MACI. They also noted larger lesions were associated with decreased satisfaction and worse outcomes for patients who underwent ACI or MACI.
“These results provide further evidence that patients suffering from patellofemoral cartilage lesions can reach acceptable (more than minimum) levels of clinical improvement in relatively large proportions,” the researchers wrote in the study.
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